Estrogen Killer follows Shanaya, a reserved psychiatrist assigned to evaluate Amar, a notorious serial killer responsible for the murders of eight women. During a series of intense interrogations, Amar recounts his traumatic childhood, warped beliefs about women, and the events that transformed him into a remorseless murderer. As the psychological battle between doctor and killer deepens, Shanaya begins questioning the thin line separating justice, empathy, and vengeance. The film builds toward a morally ambiguous climax where both characters are forced to confront the darkness within themselves.