For the past five years, Peter Parker has been the one and only Spider-Man. However, there’s no time for celebration, as Peter is facing numerous Fisk thugs wreaking havoc across New York City. Among them is a particularly dangerous and powerful thug known as The Beetle. Peter must defeat The Beetle to save the city from his reign of terror. At the same time, Peter struggles with internal conflicts stemming from his previous encounter with the alien symbiote known as Venom.