In the year 74 BC, Titus Lucretius Carus, a young man with bold ideas, tries to convince his friend Memio that moving to the city of Rome to study is a total waste of time. Years later, Lucretius returns from the capital. Trying to find a balance between his explanations of the natural world and his emotional experience of it, Lucretius lives a deep and troubled passion with his foreign wife Isa.