Based on a novel "The Battle Of The Yanagawa-Gumi" by Koichi Iiboshi, it tells the story of criminal Jiro Yanagawa. Released from prison, Jiro joins the notorious Yoshimizu Yakuza family as a member. Not long after however, he sets out to form his own Yakuza clan in Osaka. This sparks a bloody territory war with the Devils Dragons.

The movie is set one year after the events of Mafia Family Yanagawa - Part 1, in which 8 Yanagawas faced off against 100 Devil Dragons in an epic bloody battle. Jiro Yanagawa (Takeuchi Riki) continues his feud with the Devil Dragons as he attempts to usurp their western territory.

The Yanagawa-gumi challenges violent organizations one after another until a formidable man rises to block their path. This third installment depicts their story from their repeated rapid advances across the length and breadth of Japan to the eventual wave of intensified police crackdowns that leads to their disbandment.