A highly intelligent chimpanzee named Caesar has been living a peaceful suburban life ever since he was born. But when he gets taken to a cruel primate facility, Caesar decides to revolt against those who have harmed him.

A group of scientists in San Francisco struggle to stay alive in the aftermath of a plague that is wiping out humanity, while Caesar tries to maintain dominance over his community of intelligent apes.

Caesar and his apes are forced into a deadly conflict with an army of humans led by a ruthless Colonel. After the apes suffer unimaginable losses, Caesar wrestles with his darker instincts and begins his own mythic quest to avenge his kind. As the journey finally brings them face to face, Caesar and the Colonel are pitted against each other in an epic battle that will determine the fate of both their species and the future of the planet.

Several generations in the future following Caesar's reign, apes are now the dominant species and live harmoniously while humans have been reduced to living in the shadows. As a new tyrannical ape leader builds his empire, one young ape undertakes a harrowing journey that will cause him to question all that he has known about the past and to make choices that will define a future for apes and humans alike.