Seven years after the events of the first film, Samantha Darko finds herself stranded in a small desert town after her car breaks down where she is plagued by bizarre visions telling of the universe's end. As a result, she must face her own demons, and in doing so, save the world and herself.

After narrowly escaping a bizarre accident, a troubled teenager is plagued by visions of a large bunny rabbit that manipulates him to commit a series of crimes.