Welcome to Hotel Transylvania, Dracula's lavish five-stake resort, where monsters and their families can live it up and no humans are allowed. One special weekend, Dracula has invited all his best friends to celebrate his beloved daughter Mavis's 118th birthday. For Dracula catering to all of these legendary monsters is no problem but the party really starts when one ordinary guy stumbles into the hotel and changes everything!

When the old-old-old-fashioned vampire Vlad arrives at the hotel for an impromptu family get-together, Hotel Transylvania is in for a collision of supernatural old-school and modern day cool.

Dracula, Mavis, Johnny and the rest of the Drac Pack take a vacation on a luxury Monster Cruise Ship, where Dracula falls in love with the ship’s captain, Ericka, who’s secretly a descendant of Abraham Van Helsing, the notorious monster slayer.

When Van Helsing's mysterious invention, the "Monsterfication Ray," goes haywire, Drac and his monster pals are all transformed into humans, and Johnny becomes a monster. In their new mismatched bodies, Drac and Johnny must team up and race across the globe to find a cure before it's too late, and before they drive each other crazy.