In Round One - FIGHT!: Ryu and Ken find themselves setting out to investigate the murder of their martial arts master. Their search for answers takes them to Japan where M. Bison and his assorted minions including Cammy, Vega, and Sagat keep a close eye on Ryu for reasons unknown.

Legendary fighter Ryu begins his journey around the world, Cammy's quest to discover her past takes a number of turns, and Chun-Li's investigation into Shadaloo takes her from the Hong Kong underworld to the jungles of Brazil.