English aristocrat Lara Croft is skilled in hand-to-hand combat and in the midst of a battle with a secret society. The shapely archaeologist moonlights as a tomb raider to recover lost antiquities and meets her match in the wicked Powell, who's in search of a powerful relic.

Tasked by MI6 to find the mythological Pandora's Box, an ancient object supposedly containing one of the deadliest plagues on Earth, Lara Croft must beat evil Nobel Prize-winning scientist turned bioterrorist Jonathan Reiss to it.