A young couple, Rosemary and Guy, moves into an infamous New York apartment building, known by frightening legends and mysterious events, with the purpose of starting a family.

Baby Adrian is now all grown up and separated from his mother, wrestling with the occult influences that plague him, and trying to outrun Satan himself.

When a struggling, young dancer suffers a devastating injury, she finds herself drawn in by dark forces when a peculiar, well-connected, older couple promises her a shot at fame.