Wrongfully convicted of murdering his wife and sentenced to death, Richard Kimble escapes from the law in an attempt to find the real killer and clear his name.

U.S. Marshal Sam Gerard is accompanying a plane load of convicts from Chicago to New York. The plane crashes spectacularly, and Mark Sheridan escapes. But when Diplomatic Security Agent John Royce is assigned to help Gerard recapture Sheridan, it becomes clear that Sheridan is more than just another murderer.