Gru is a supervillain determined to prove he’s the greatest by stealing the Moon. To pull off his plan, he adopts three orphaned girls—Margo, Edith, and Agnes—intending to use them as part of his scheme. However, as Gru bonds with the girls, his cold, villainous exterior begins to melt.

Gru is recruited by the Anti-Villain League to help deal with a powerful new super criminal.

Gru and his wife Lucy must stop former '80s child star Balthazar Bratt from achieving world domination.

Gru and Lucy and their girls—Margo, Edith and Agnes—welcome a new member to the Gru family, Gru Jr., who is intent on tormenting his dad. Gru also faces a new nemesis in Maxime Le Mal and his femme fatale girlfriend Valentina, forcing the family to go on the run.