In the land of Oz, ostracized and misunderstood green-skinned Elphaba is forced to share a room with the popular aristocrat Glinda at Shiz University, and the two's unlikely friendship is tested as they begin to fulfill their respective destinies as Glinda the Good and the Wicked Witch of the West.

As an angry mob rises against the Wicked Witch, Glinda and Elphaba must unite one last time with honesty and empathy to fulfill their shared destiny and change the fate of Oz forever.