In this moving film Horizon follows the Loughran family in their fight to save the life of their daughter Sheila who suffers from cystic fibrosis. They lost their youngest daughter Ann to the disease in 1974 at the age of 15, and now as the health of their third daughter Sheila deteriorates, they must face the prospect of losing a second child. The current shortage of donor organs means that Sheila's only hope of survival is a rare and controversial operation that requires her two surviving siblings to undergo an arduous and potentially fatal operation. An X-ray of Shelia's lungs Cystic fibrosis (CF) is the most common genetic disease in this country and it is incurable. The lungs of people with cystic fibrosis become covered with a sticky mucus making them extremely susceptible to bacterial infection. Over time these infections badly scar the lungs, until eventually they stop functioning. The defective CF gene is harmless when only a single copy of the gene is inherited. However, b