When a student is found dead during a college-based clinical trial for a new anti-depressant, Lewis and Hathaway struggle to determine whether the incident was murder or suicide, and receive little assistance from the institution's evasive psychiatric professor. A second student's death then leads to the revelation that the trial's participants are all operating under the influence of mind-altering drug ketamine, and that the lines between love, obsession and madness have become dangerously blurred.