An unprecedented series of violent tornadoes is sweeping across Oklahoma. Tornado chasers, headed by Dr. Jo Harding, attempt to release a groundbreaking device that will allow them to track them and create a more advanced warning system. They are joined by Jo's soon to be ex-husband Bill, a former tornado chaser himself, and his girlfriend Melissa.

As storm season intensifies, the paths of former storm chaser Kate Cooper, lured back to the open plains after a devastating encounter years prior, and reckless social-media superstar Tyler Owens collide when terrifying phenomena never seen before are unleashed. The pair and their competing teams find themselves squarely in the paths of multiple storm systems converging over central Oklahoma in the fight of their lives.