Two frantic parents have lost their children and fears that they have left the hospital while visiting their sick great-grandfather. They have been captured on CCTV outside the hospital, but haven't been seen since. A stricken rape victim is brought in, tied with copper wire. Dad knocks on the flats around their home, and comes across a convicted pedophile, who looks shifty. Meanwhile, police have found a bloodied hood, belonging to the girl.

Family friends, police, even hospital staff have rallied around in a desperate search for Adam and Kayleigh. Paramedics Luke and Nina are searching in the sewers for them and come across Adam and Nina goes to save him, but falls and is feared to be paralysed. Adam is in critcal condition and now Lee, a neighbour, is number one suspect after Adam and the rape vitcim have been tied with copper wire, found in Lee's van. Across a river, Kayleigh's body is found and Lee is arrested.

The staff of Holby A&E bid a sad goodbye to friend and colleague Roxy Bird who sets off for a new carreer as a nursery nurse. However the drama happens mainly to Fin who has to go into a burning building to save trapped schoolgirls one of them being his daughter but as everyone manages to survive the shock to follow is when a man blames Fin for his wifes death after he wouldn't treat her because of his heroic actions. Elsewhere Nina appears to be falling for Abs big time

New doctor Selena Manning makes a return to Holby A&E after working at the hospital for a brief spell 18 months ago. The police doctors first day gets off to a good start, she happens to bump into Harry who she nearly slept with when she was last on the wards of Holby. However after laughing and joking about their last meeting together Selena arrives home for a big shock - her husband in bed with hospital receptionist Bex. As Fin goes to a press conference to discuss his heroic actions following the fire he ends up being branded a killer by grieving widower Karl.

Comfort and Fin are shocked and a bit scared this week when they arrive at a shout and when they return to the ambulance it is trashed. Not realising it could me Karl whose wife Fin left to save his daughter from a fire could be involved Fin brushes it off as kids messing about. Things take a later twist when Comfort tells Tess that she is pregnant and will surprise Fin when she cooks a romantic meal for the two of them later on. However Fin never turns up. Meanwhile Tess tells her son Sam not to tell anyone he is her son as he applies for the receptionist job at the hospital and after finally agreeing to go out on a date Abs and Nina's night is ruined when Ellen unexpectedly turns up. Contributor: Adam Hague State

Comfort reports Fin's disappearance when he does not return home and no one has heard from him. Tess' son Sam arrives as a new receptionist and gets off to a bad start with co-receptionist Bex when he arrives late. He also hides the fact that Tess is his mother after Tess tells him it would be better that way but Bex discovers the truth. Meanwhile Ellen tells Abs she may have to leave the country soon as she is running out of money. He is further shocked when she confesses that she is terrified to return to her father as he abuses her. Also Luke turns up at Kate's house to try and help her but will she her husband's 'killer' to help her out of her abusive relationship and Selena bins a bunch of flowers from her husband Will.

Comfort turns to Tess for support as news of Fin's disappearance hits the papers. Nina hits the roof this week when Abs reveals why Ellen can't leave the country. Later on Nina gets a shock when she walks in on Ellen kissing Abs but is everything as it seems. Meanwhile Josh has to break up a fight between Luke & Kate's boyfriend.

Comfort starts to really worry about the disappearance of her husband Fin tonight. Josh discovers Fin's knife in a patients pocket who confesses he found it. After overhearing the police discuss where the knife was found Comfort rushes straight over there. As the police search for Fin, a body is found and Selena is called to pronounce a death but is the body Fin's.Elsewhere Luke invites a beat up Kate to stay at his house to escape her abusive partner.

Abs is shocked when Ellen asks him to marry her this week. He is even more shocked when she reveals that the only reason she wants to marry him is because her visa is running out. When she sees how taken aback Abs is, she tells him she can't go back Ukraine because she will have to face her abusive father but is Ellen telling the truth? Also Comfort is asked to identify a body and breaks down when the body is Fin.

Comfort faces a double blow this week when Tess shows her an article in the newspaper which includes an interview with Fin's wife. After storming round there she comes face to face with Fin's wife Ruth but refuses to believe her. She is then introduced to Fin's son but still won't believe Ruth. To add to her problems she then finds out Fin was murdered. Sam and Bex enjoy a night on the town which leads with Sam facing the brush off from Bex and Abs considers marrying Ellen but in the end he tells her he wouldn't be able to go through with her. Contributor: Adam Hague

Things go from bad to worse for Comfort at Fin's funeral when she collapses with stomach pains. After being rushed to hospital Comfort is told her baby is alive but how much more heartache can Comfort take? Elsewhere Ellen continues to get Abs to agree to marry her so she can stay in the country but he tells her that in no way he will marry her. Guppy re-thinks his decision to be a doctor after yet another mistake and after keeping quiet about being given the brush off by Bex, Sam tells Bex he is embarrassed by their not so active night.

Harry starts the investigation into what happened to the patient who suffered a cardiac arrest. Abs and Ellen are interrogated by Harry and desperate to stay in the country Ellen says she will cover for Abs but only if he marries her. Facing been struck off Abs reluctantly agrees. Also Comfort discharges herself from hospital determined to keep her pregnancy a secret.

There's a dramatic rooftop showdown this week when Comfort comes face-to-face with her husband, Fin's killer. With murderer Karl about to jump Comfort tries to talk him round so that justice can be done but after things get heated Comfort just has to know why Karl did it and as an argument entails Comfort watches as Karl jumps to his death. Is Comfort's nightmare finally over? Elsewhere Ellen reveals her and Abs wedding plans much to the shock of their friends and colleagues.

New paramedic Woody gets off to a bad start when he is caught in a sauna naked and has to be brought into Holby A&E. Selena declares war on Bex. Jim becomes worried about his forthcoming court date in the USA and Abs confides in Claire the real reason he is marrying Ellen.

After finally enjoying herself while at the Christmas party things go back to bad for Comfort when she arrives home and finds Ruth has moved into her flat and she is homeless. Selena continues to harass Bex and Abs finds Sam tending to a patient.

After Nina begs Abs not to marry Ellen because she loves him Abs has a lot of decisions to make but in the end marries Ellen to help her stay in the country leaving Nina heartbroken. Tess gets a shock when she goes round to Comfort's flat after work and finds Ruth, Fin's other wife there. Things go from bad to worse for Jim when he's struck off.

Crossover with Holby Ciy; for part 2, see Casualty@Holby City (2) Catastrophe hits Holby A&E when a truck carrying petrol crashes into the hospital. Even though only at the hospital to collect his things after been struck off, Jim is thrown into the center of the accident when he has to help Holby City character Rosie save a baby's life while Bex's life is put in danger when she takes a man to the drugs section of the hospital to help him find a doctor but it takes a sinister turn when he takes her hostage to help him get drugs for himself. Elsewhere Harry and Luke try to help out in the hospital another explosion happens leaving Bex, Jim and others lives in danger.

Everyone grieves for Jim while Harry raises awareness on the wards which ends in a shock when Charlie returns from Canada. Ellen receives bad news about her visa and Selena continues to bully Bex.

Ellen starts to panic when she finds out her fathers coming to visit and ends up missing her immigration meeting. McFly pop by Holby A&E to surprise two fans who went a long way to meet the famous pop band. Comfort is furious to find Sam tampering with her marriage certificate leading to an argument between Tess and Comfort.

Comfort faces more heartache this week when the pregnant paramedic is rushed to hospital with stomach pains and although it looks like the baby's alive but critical things take a horrible twist when she loses her baby resulting in Comfort blaming herself. Also Ellen faces problems when her father arrives early and Nina tells him Ellen told Abs he abused her. Disgusted in his daughters lies he tells Abs and Nina the truth, Ellen is in the country ilegally after fleeing the country after being charged with fraud. Elsewhere Bex throws Charlie a birthday party to remember.

Abs continues to ignore Nina & Ellen continues to try to get back into his good books which leads to Abs finally snapping at Ellen and throws her out into the streets. Sam continues to act very oddly and his mum Tess still oblivious to her son's odd behavior throws all her effort into getting Comfort the break she needs by jetting her off to Barbados to spend time with Fin's family. Meanwhile Bex thinks she's found Mr Right in Pete.

Abs gives Ellen her marching orders when he catches her lying again. Tess gets a shock when she spots her son Sam burning patients files outside the hospital. Meanwhile new registrar Maggie stops at the scene of an accident to help out, and Charlie receives a mysterious e-mail.

Abs finally stands up to Ellen by threatening to tell immigration about their 'fake' wedding but she then turns nasty. She also makes a big mistake with a patients treatment. Has Ellen made her final mistake? Woody and Luke play a practical joke on Harry, Charlie and Selena. Guppy stands up to his father. Bex feels down after finding out about Pete's cheating ways and Tess really starts to worry about Sam's state of mind.

An inebriated Bex pesters Pete all night after she sees him with another woman at the Valentine's Ball, but the evening soon takes a horrific turn when he decides to walk her home. Meanwhile, Guppy refuses to bow to his father's bullying, Tess remains in denial over Sam's increasingly delusional behaviour, and the net closes in on Ellen. Contributor: Soapaholic State: Un-approved

An emotional Bex reports her rape to the police, but then learns that the doctor who will be examining her is Selina, her arch enemy. Selina is a source of comfort, however, especially when Bex has doubts about pressing charges. She encourages her to ensure Pete doesn't get away with his crime. Meanwhile, faced with a possible murder charge over the death of a patient she neglected, Ellen disappears into the night. Contributor: Soapaholic State: Un-approved

As Sam's condition worsens, Tess and Mike are forced to take him to see a psychiatrist. The day however takes an unexpected turn when after an argument with Tess, Mike storms off and is involved in a car accident. How will Tess cope with this added strain in her life? Elsewhere Harry reveals his very delicate financial troubles to Charlie. Luke supports Bex as she tries to deal with her rape ordeal and an immigration officer interviews Abs and Nina over Ellen's whereabouts.

Tess is told to withdraw Mike's treatment and let him pass away but a miracle happens when he begins to come round. Are things finally looking up for Tess? The paramedics face a tough day when they are called to an accident at the docks which sees Woody save a boy from drowning even though he can't swim, putting his own life in danger. Nina has to give drugs to a critically ill woman but if the drugs don't work Josh's neck will be on the line for letting her. Meanwhile Luke continues to help Bex through her rape ordeal.

Bex returns to work only to be put down by Claire at every available oppurtunity. Following this Bex drowns her sorrows in vodka and the diabetic receptionist collapses in the bathroom while Charlie and Selena find her will she survive? Abs and Nina get closer while Tess breaks down in front of Harry over her family problems and Guppy is comfronted by a face from the past.

After Bex survives her suicide, Charlie advices Claire to take some time off work then Claire shares a secret kiss with Luke behind Bex's back. Abs is visited by a loan shark who says Ellen owes him £5000 and he wants it back off Abs. Tess tells Sam the truth about Mike.

Selena is faced to work with her ex-husband Will on a police related case and as he thinks she wants him back, she tells him she wants a divorce. Luke feels guilty after his kiss with Claire and Nina tells Abs they can escape Ellen's debt by doing a runner.

Bex returns to work this week and looks back to her old self but when Claire talks to her about Pete's court case Bex breaks down. Later on Bex thinks she sees Pete outside her house so calls Luke and after being told he's no where around Bex decides she can't carry on this way and decides she can't carry on with the court case. Elsewhere Tess brings Sam home from the psychiatric hospital sooner than planned leading to an argument with Comfort. Will puts obsticles for Selena to divorce him. Abs steals money from a dead womans bag to pay off Ellen's debt but is persuaded to put it back after Nina threatens to end their relationship if he doesn't and Guppy helps out a young girl who's brother is dying.