The series opens on a seemingly ordinary day, October 6, 2009, which soon becomes extraordinary when at 11:00 a.m. Pacific Time, as everyone in Los Angeles blacks out for two minutes and 17 seconds. It soon becomes apparent the blackouts were worldwide, and were accompanied by a "flashforward" where each person saw what might be his or her life on April 29, 2010, roughly six months into the future. FBI Agent Mark Benford and a team of agents in Los Angeles begin gathering clues as to what might have happened as they struggle to come to terms with their own visions, or in Demetri Noh's case, a lack of one. Meanwhile, Mark's wife Olivia, and daughter Charlie, each have disturbing visions of the future with which they must cope. As the episode closes, FBI Agent Janis Hawk makes a startling discovery: an image from CCTV in Detroit of a man in black, walking through the stadium while everyone around him is unconscious.

Mark and Demetri go to Utah to investigate a lead on a suspect who might have a connection to the global blackout. Olivia sees the man from her flashforward, while her daughter Charlie is having trouble dealing with hers.

Mark and Janis arrive in Germany to discuss the past events regarding the blackouts. Demetri fears about his future. Meanwhile, Aaron tries to get Mark to help him with an appeal.

Olivia struggles to accept Bryce's suggestion that a patient's flashforward holds the key to a correct diagnosis and treatment. Meanwhile, Demetri accuses Mark of waiting for the future he saw in his flashforward to come true without incident, while Mark feels Demetri is letting his fear of what he witnessed envelop his life; and Nicole returns to work as Mark and Olivia's daughter's baby-sitter, and discloses her shocking future vision — involving a murder.

Mark finds himself on the defense while being questioned about the details of his flashforward during a Senate Intelligence Committee hearing, which will decide whether to continue funding Wedeck's team. Meanwhile, Janis wonders how her flashforward will affect her current romantic relationship, and Olivia receives an anonymous message relating to Mark's flashforward.

Mark, Demetri and Wedeck try to connect Janis' attack with a separate attack made on them; Olivia confronts Mark about his flashforward; Demetri and Gough track down a clue from Mark's flash; Dylan goes missing from the hospital

Mark, Demetri, Gough and MI6 agent Fiona Banks investigate a Blue Hand club and its possible connection to some recent suicides. Meanwhile, Aaron receives a surprise visit from a former army buddy of his late daughter's, Demetri comes clean with Zoey about his lack of a flashforward, and Nicole helps Bryce uncover the mystery of his flashforward while volunteering at the hospital.

Mark cuts his romantic getaway with Olivia short when a tip leads to the discovery of the tattooed assassin seen in his flashforward, Simon and Lloyd settle a debate over a game of poker, Aaron learns the truth about daughter Tracy's deadly accident, and Janis returns to work but debates her future with the department.

Bryce begins his search for the woman in his flashforward, Aaron becomes concerned over Tracy's odd behavior, Mark attempts to track down the person responsible for texting Olivia and outing his drinking during his flashforward vision, and Demetri's co-agents try to find the mysterious caller who forewarned him about his unfortunate fate.

Against Wedeck's orders, Mark and Demetri travel to Hong Kong in search of the woman claiming to know details of Demetri's fate; Lloyd tries to come clean about his and Simon's involvement in the global blackout - against Simon's better judgment -- and Zoey discovers the true meaning of her flashforward.

Mark is suspended from duty at the FBI and must meet with a Bureau-appointed therapist in order to regain his badge; Demetri reluctantly teams with CIA agent Vogel to continue the search for Lloyd, while a suspended Mark resumes his own investigation into his disappearance; with Lloyd missing, Simon attempts to hack into his computer in search of clues; Janis is assigned to accompany Simon and learns some family secrets about him; and Nicole speaks with a man who was transformed during the blackout in order to help her restore her faith and understand her horrific flashforward vision.

Janis goes with Simon to Toronto and learns some family secrets.

Aaron delves deeper into why the black-ops Jericho unit is after his daughter. Later, his daughter goes missing, and he suspects his daughter's friend. Mark continues to question Lloyd about a phone conversation that took place during their flashforwards, and finds out he knows D. Gibbons. Also, Zoey tries everything in her power to change Demetri's fate. Timbaland guest stars.

Demetri, Janis, Simon and Vogel travel to Somalia in search of clues to a mysterious tower and encounter a dangerous man who saw his fellow villagers black-out in 1991; Bryce tells Nicole that he has cancer; and Olivia attempts to get daughter Charlie to tell her what she saw in her flashforward.

Mark and Vogel put a plan into action to uncover the FBI mole, which could end up alienating Mark from his co-workers. Meanwhile, in an effort to protect his family and his marriage Mark moves out of the house, and Keiko continues her search in Los Angeles for Bryce and finds employment at the unlikeliest of places.

Demetri decides to put a rush on his wedding plans with Zoey when the captured FBI mole confirms the date of his prophesized murder; Wedeck tries to help Aaron infiltrate Jericho in order to rescue Tracy; and Olivia's friendship with Lloyd grows stronger.

The clock is ticking on Demetri's life as Mark and his team go in search of his whereabouts; terror suspect Alda Herzog promises to give Zoey intel on where Demetri is - but at a price; and Olivia learns the identity of the person who sent her the text message informing her that Mark was drinking in his flashforward.

Janis continues to thwart her fellow FBI agents as an inside mole to a mysterious employer; Olivia is given some disturbing news by Gabriel, who has been subjected to numerous flashforwards; and Aaron's life is in danger in Afghanistan when he tries to blend in with the locals as he continues his search for his daughter.

Demetri and Agent Banks attempt to track down a killer as questions arise about the universe course-correcting itself, when people who thought they'd escaped their fates are found dead; Mark reluctantly agrees to help Simon find his sister, Annabelle, but discovers he's withholding the truth about her true circumstances; the FBI discovers the identity of Suspect Zero; and Nicole learns the whereabouts of Keiko - the woman in Bryce's flashforward - but struggles with whether to share this information, due to her growing feelings for him.

It's April 28 - the day before the prophesized flashforward date - and as the world waits to see if their future visions will come true, Mark must do everything in his power to protect Gabriel, who is the bridge between Dyson Frost and the Global Blackout; Aaron locates his daughter's captors and puts his life on the line in order to rescue her; Janis is tasked with killing a fellow agent; and Simon comes face to face with the head of the nefarious organization that may be responsible for the blackout.

Mark continues his interrogation of Hellinger in a desperate attempt to find out when the next blackout will occur; Demetri must choose between helping Janis and Simon break into NLAP to stop the blackout from occurring, or turning the fugitive Simon in to the FBI; Lloyd finds the common denominator that can help him solve the complex equation he was working on in his flashforward; while Tracy fights for her life, Aaron discovers why Jericho was after her; and Nicole wrestles over her strong feelings for Bryce and what would happen if she told him she knew the whereabouts of Keiko.

It's D-Day - April 29, 2010 - and while everyone waits to see if their flashforward visions come true, Mark uncovers the date of the next blackout, and Simon, with Demetri, attempts to stop it from happening by breaking into the NLAP mainframe.