When Mandy discovers that a mysterious source has created a social network called Mandybook in her honor, she's thrilled, especially when she gets over 100,000 followers within the first hour! But things quickly go downhill when her followers literally start to follow her, and not in a good way. What Sam, Clover, and Alex eventually uncover, after Jerry sends them on a mission to investigate a strange, mind-controlling frequency emanating from somewhere near their campus, is that the network's creator, Telly Hardwire, is to blame. In an effort to get revenge on Mandy for not wanting to be his cyber-friend back in high school, he has engineered Mandybook to be a recruitment tool to create an army to take her out! In a B-story, Clover is upset when her Fashion Design teacher, Professor Plunkett, is impressed with Sam and Alex's designs but not hers.

Bizarre occurrences across the globe prompt Jerry Lewis to send the spies on a mission to check things out. What they discover is that someone (or something) is slowly turning the world into what appears to be a giant cat habitat! Back at Malibu University, Alexandra volunteers at the animal lab with a peculiar woman, Feline Dion, who is doing extensive research on cats. Meanwhile, the spies discover that a half-cat, half-human hybrid is responsible for the chaos around the world and all signs point to Feline. What's more, Alex has been affected by Feline's experimental cat DNA serum and is now turning into a cat-human hybrid. Can the spies stop Feline (before she turns everyone in the world into cat people) and help Alex before it's too late? In a B-story, Clover tries convincing her mom, Stella, that she is studying to become a medical doctor while she is at Malibu University.

They began to disappear game developers. Spies sent on a mission, and suddenly fall into a video game.

When it's time to watch their fave TV dance competition show, Sam, Clover and Alex are stoked, especially because they think the host is way cute.

When there's a break-in at the Lab, Sam, Clover and Alex discover that a top-secret, age-reducing serum has been stolen. When Jerry does a scan on a hair the girls found, he discovers it belongs to Bertha Bombshell.

People are found in a defunct amusement park after getting attacked and abducted in Hawaii. Plus, Mandy finally decides to get a bodyguard.

Someone is rigging designer wedding dresses to destroy the brides to be big days. That someone turns out to be Wera Van, who is bent on getting revenge on the world who rejected her designs.

The spies investigate the mysterious disappearance of high-profile celebrities. Plus, a talent scout checking out Mandy becomes more interested in Oinky.

When banks are robbed without resistance from bank employees, the spies learn that Granny has been using a mood-altering substance in her cupcakes.

Sam, Clover and Alex discover two otherworldly men are battling it out in the streets, searching for a mythical Heart of Grentoid object.

When there are reports of famous show dogs vanishing all over the world, the girls travel to New York to investigate.

The girls are surprised to find that Mandy has launched a set of action figures called Mandy Dolls that have become extremely popular in town.

The spies are sent by Jerry to investigate when people around the world are found mysteriously frozen in blocks of ice.

When top designers around the world begin disappearing, Jerry puts the girls on it. Their investigation leads them to the White House.

When Jerry informs the girls that they're once again setting sail aboard the WOOHPtanic, they are psyched, but things quickly go awry when the ship is unexpectedly attacked by Salty Schooner, an evil pirate bent on making the vessel his own.

Trent accidentally stumbles upon the spies as they apprehend a ridiculous scorpion villain, witnessing them in action.

The spies are sent to investigate when bizarre things begin to happen to the natural wonders of the world - they're being transformed into giant skate parks.

During a routine check, Jerry encounters a most unexpected event; Sam, Clover and Alex start to realize that something is definitely up.

When people around the world suddenly turn up with crazy clown makeup all over their faces, Jerry sends the spies to investigate.

Jerry has the spies investigate bizarre tide patterns that pop up around the world, and what they discover is out of this world.

When Jerry calls the girls in, they think they're going to be called upon to do battle. Instead, they're given the mission to transport three villains to an island prison.

The spies have their vacation interrupted, and they have to battle plants which have turned against them.

The spies are ordered to investigate when a celebrity from a children's show is kidnapped live on air.

When Jerry informs Sam, Clover and Alex that they'll no longer be working as a team, but as solo agents instead, the girls are shocked.

Sam, Clover, and Alex, along with the rest of Professor Plunkett's Fashion Design class, win a trip to Versailles where they will be guests at a fashion show.

The spies discover that something strange is happening after the attacks in the palace, and find themselves involved with a theft.