Henry VIII weds a third time: to shy, demure noblewoman Jane Seymour, a union that he and his advisors pray will result in a male heir; once-loyal subjects rebel against Henry's crusade against Catholicism.

The rebellion now known as the "Pilgrimage of Grace" begins in earnest, with Henry dispatching Brandon to deal with the uprising; bedridden due to the recurrence of his jousting injury, Henry takes a new mistress: Lady Ursula Misseldon.

Henry reconciles with his estranged daughters Mary and Elizabeth in time for the Christmas holidays, but betrays and brutally suppresses the rebellion against him after making conciliatory promises to the uprising's leaders.

The leaders of the Pilgrimage of Grace uprising are put to death, but Brandon is disturbed by the cruelty and mercilessness of the suppression; Henry celebrates the birth of a son but his joy is short-lived as Queen Jane dies within days.

Henry remains in seclusion while mourning the queen's death, an opportunity that enemies of the crown seize to murder several friends of the court; Cromwell is disturbed when Henry doesn't resist his new church's similarities to Catholicism.

Matchmaking begins in earnest as Cromwell schemes to secure the Reformation by marrying Henry to a Protestant wife - but the king's marital reputation precedes him; the condition of Henry's wounded leg turns life-threatening.

War looms with France and Spain aligning against England with backing from Rome, so Henry agrees to a politically fortuitous marriage with Anne of Cleves, a plain and unsophisticated German aristocrat he has never met.

Henry moves swiftly to annul his loveless marriage to Anne of Cleves, and beds a new mistress, 17-year-old Katherine Howard; Princess Mary falls in love with Duke Philip of Bavaria; Cromwell's fall from favor is sudden and dramatic.