An elderly scientist named Adrian Toomes plans his revenge against Norman Osborn after accusing him of stealing his flying technology. Donning his own flying suit, Toomes takes to the skies to enact his revenge and it's up to Spider-Man to stop him. Peter is concerned that Aunt May is running out of money. He tries to make money for the two by making a deal with J. Jonas Jameson that if Peter can get pictures of Spider-Man in action, Jameson will pay Peter money.

An electrician named Max Dillon becomes the supervillain known as Electro after a freak accident and it's up to the Spectacular Spider-Man to stop his rampage. Meanwhile, Peter tries to tutor the popular Liz Allen.

Peter Parker and Spider-Man both must learn to own their choices when decisions made by Dr. Curt Connors transforms Pete's mentor into The Lizard.

While Peter Parker resists taking on the responsibility of helping Aunt May pay the bills, Montana the Big Man's Enforcer - becomes the stunning Shocker to fulfill his responsibility: eliminating the Spectacular Spider-Man.

Peter Parker and Harry Osborn try out for the football team -- and become a bit obsessed with going for the glory. Flint Marko, newly transformed into the Sandman, is out for glory too -- at the expense of our friendly neighborhood Spider-Man.

Peter Parker struggles to get a date for the Fall Formal, and to figure out a way to pay for it. Meanwhile, the unstoppable Rhino – the latest of the Big Man's creations – has sworn vengeance on Spider-Man. Spidey takes the battle directly to the source of his troubles, the previously invisible hand, who has been secretly conducting his villain-of-the-week attacks.

Peter Parker and Mary Jane Watson go to the Midtown High Fall Formal. Meanwhile, Norman Osborn conducts a new experiment on himself, thus becoming the Green Goblin. Then, Green Goblin tries to take down L. Thompson Lincoln.

Tired of constantly being pushed around by others, the timid Otto Octavius has his robotic arms permanently attached to his back and becomes the deadly Doctor Octopus.

Spider-Man is pitted against the Green Goblin, Hammerhead and Tombstone while Colonel John Jameson attempts to land a damaged space shuttle.

The Chameleon is out to blacken Spider-Man's name. The master of disguise loots the city while borrowing Spidey's look, forcing Peter Parker to get help from Black Cat.

Six of Spidey's toughest enemies band together to get revenge, as the Sinister Six!

Spider-Man loses the black suit, accidentally creating the Venom.

Peter must face off against his greatest enemy and friend, The Venom.