After ten years as an FBI profiler, Frank Black relocates from Washington to his hometown Seattle with his wife, Catherine, and their daughter, Jordan. However, a series of sexual homicides coaxes him from retirement. He offers his support to Lt. Bob Bletcher, a former colleague with Seattle's Homicide Unit, and is in turn offered the resources of the mysterious Millennium Group, a corps of former law enforcement officers. Blessed - or afflicted - with an uncanny ability enabling him to see the world through the killer's eyes, Frank must pursue the murderer through Seattle's underground scene and stop his killing spree.

When human ashes are found in a local park, Frank Black joins an investigation that leads to a cult that kills it's unwilling members. When Frank gets closer to the cult leader he sees the force that may be influencing the killers he seeks.

Against the initial resistance of the Group, Frank travels to Portland, Oregon, to investigate a murder at an animal shelter. He meets with Jim Horn, a profiler and candidate for the Millennium Group. But Horn is distracted by his imminent divorce, and there is tension between him and Frank. When the killer strikes again, Horn is losing control, and Frank not only has to catch the killer who leaves grisly messages on his victims, but he has to contend with Horn as well who is more than ready to stop the murderer with terminal prejudice.

When Annie Tisman opens a parcel containing a human tongue, Bob Bletcher asks Frank Black for help. This is the fourth package within the last four years containing fingers or other members cut from living victims - but no bodies were ever found. When Cheryl Andrews, expert pathologist of the Millennium Group, checks the tongue she discovers that it has been removed postmortem - the killer has changed his MO. When Bardale, a career criminal, is released from prison, a man who introduces himself as the Judge makes him an offer - to carry out his verdicts in exchange for immunity. His first job: to kill his predecessor, a man named Carl Nearman who botched the last job, the killing of former police officer Jonathan Mellen. Mellen's body is discovered in the woods. When Frank visits the morgue, Carl Nearman's body is on the table. In a vision he sees a connection between Mellen and Nearman. When Catherine tells him that Annie Tisman's husband died twelve years ago in prison where

Frank and Peter assist an FBI investigation when a mad bomber terrorizes Washington, D.C, by blowing up buildings then to come out looking like a hero, the bomber goes back into the wreckage to save victims. Frank and Peter help search for the bomber whose attention starved personality may be the key to his undoing.

A desperate man sets out on a killing spree taking revenge on the holy men that he believes have led him to stray. Frank can see the man's sense of faith and the lack his faith could be the key to stopping this killer. Frank then puts himself in danger when he walks into a hostage situation at a small town church.

A juvenile delinquent begins taking advantage of families grieving the loss of a loved one with the support of a sadistic friend to a murderous end. Frank Black puts himself in the troubled boy's frame of mind to find answers as Catherine looks elsewhere, into the boy's tortured family life.

Catherine aids a woman who has been sexually abused by her father for twenty-three years. Catherine however finds it hard to find anyone who will take this case to court, so she turns to Frank for emotional support.

A young girl whose parents were brutally murdered becomes the last hope in finding a killer. So Catherine encourages Jordan to speak out to the young girl and try to get her to get over the awful experience she has been through. But Bletcher is determined to let the relive what happened so they can get more evidence about what actually happened.

Frank searches for answers when a couple kidnap a killer-in-hiding and engage in their own murder spree. Frank must track them down before they find the baby the girl's father sold to a childless couple, because Frank fears they could be next victims.

Frank pursues a killer who kidnaps teenagers from an upper middle-class neighborhood and forces them to drink human blood. After one is killed and the other is returned home unharmed because his father admitted to making a mistake, Frank is forced to set up a trap to capture the killer before he can harm the third victim.

A pharmacist drugs unsuspecting couples and forces them to enact his sexual fantasies that he cannot carry out with his wife. Will Frank and the Millennium Group be able to end these crimes before he can strike again?

The Millennium Group investigates the suicides of identical twin girls born seven years apart. They soon find out that a man and his bizarre family of cloned daughters are preparing for the apocalyptic disaster of May 5th, 2000, when a celestial alignment of the planets take place.

When Frank links two seemingly unrelated murders he finds that a killer seems to be committing murders in the exact style of serial killer Richard Hance, whom Frank put behind bars twenty years ago. The case warrants Frank's attention, and he is forced to his personal demons before he can help Bletcher track down the copycat killer...

Frank Black's private and professional lives clash when his sister-in-law is abducted by a convicted sex offender at her child's baptism. Although Bletcher orders him to stay out of the investigation because he is too close to the case, he cannot help but become involved. However, even his extraordinary abilities might not be enough to find his brother's wife...

A man confesses to murdering his family, but Frank doesn't believe him.

Franks wakes up in an alley with both memory loss and the strange feeling that someone was murdered.

Frank investigates the disappearance of a former nemesis, Dr. Ephraim Fabricant, and learns that his family may be the target of a murderer.

Frank and Peter investigate a series of Satanic murders and get caught in a battle between good and evil.

Frank tries to stop a killer of horses before he escalates.

Frank and Peter track a Russian killer with links to Chernobyl. They discover that he might be the Antichrist.

Frank is asked by Catherine's father to investigate a case involving a friend whose son has been convicted of murder, and is soon convinced that the murder is linked to a serial killer called The Woodsman. Having claimed his latest victim, the Woodsman takes the body to a secluded campsite, covers the body in plastic, buries her under a pile of leaves and strikes up a conversation. Later, he is given photos by a mysterious stranger and asked to use them as 'targets' for future killings - one of which includes Catherine Black...