Lizzie has her first boyfriend, named Ronnie, who is the local neighborhood paper boy. Lizzie is completely head-over-toenails in love with him, and Miranda and Gordo are fed up listening to Lizzie talk about him all the time. However, Lizzie is heartbroken when Ronnie breaks up with her to go out with a girl from his school. In the end, Lizzie is consoled by Gordo. Meanwhile, Matt needs only one baseball card to complete his card collection but only Melina has it. Melina agrees to give the card to Matt, but only if he does her homework and other chores for her.

Lizzie, Miranda and Gordo are obsessed with a Mexican game show, "El Oro de Montezuma" ("The Gold of Montezuma"). Miranda's cousin Carlos from Mexico City is scheduled to compete on the show and Lizzie and her friends decide to be in his team. Meanwhile, Matt and Lanny play an extreme version of Hide and Seek.

Lizzie and her mom become best friends after reading a book in social studies. She even convinces Gordo and Miranda to bond well with their parents. But in the end, Lizzie realizes that it would take some time to be more intimate with her mom. Meanwhile, Matt and Lanny find a chimp which creates havoc in the house, for which they both are blamed.

When Kate dislocates her shoulder during cheerleading practice, Claire usurps Kate's position as captain. Lizzie helps Kate regain her popularity and a place in the cheerleading squad. Matt is excited to be in a school play and acts arrogant about it. He starts bossing his parents and Lanny around, but in the end he loses his voice and learns a lesson in humility.

Miffed with her parents for not raising her allowance, Lizzie gets her first job as a busboy at the Digital Bean. But to Lizzie's surprise, it is a lot worse than she ever suspected it would be. Matt has some problems with Melina and turns to Miranda for advice. In the process, he develops a huge crush on Miranda, much to her horror and Gordo's amusement.

Lizzie, Miranda and Gordo have a fight and stop talking to each other. Meanwhile, Kate and Gordo, Miranda and Larry, Lizzie and Ethan, are paired up for a treasure hunt-styled school project. Matt comes to know of it and, unknown to them, beats them to the finish line. As the school project progresses, Lizzie, Miranda and Gordo realize the worth of their friendship and renew their ties.

Lizzie baby-sits Matt once again, with Matt deflating their father's prized autographed football. They work all day to get it back.

Gordo encourages Lizzie to finally do something about her crush on Ethan Craft -- that is, ask him to the Sadie Hawkins Day dance. When Lizzie asks Ethan for the dance, he disappoints her by saying he likes her as a 'friend', and does not want to risk changing it by going out with her. Lizzie then tries to change her image in order to please Ethan, but he still lets her down by saying they don't have a lot of chemistry. Matt and Lanny open a club in their backyard and their beverage becomes quite popular. But in the end, they are forced to shut it down.

In this Freaky Friday-inspired episode, Lizzie and Matt switch bodies for a day. Matt (in Lizzie's body) and Lizzie (in Matt's body) go to each other's school and end up in amusing situations. They both solve each other's problems at school but the next day, they return to their normal selves, leading Lizzie to wonder whether it was all a bad dream.

Lizzie has a hard time standing up for Miranda when she is accused of shoplifting. This creates a rift between both of them, causing them to choose different dance partners in their dancing class in P.E. However, in the end both realize their mistake and become friends again. Meanwhile, Matt hosts a talk show along with Lanny on the internet.

Lizzie starts feeling inferior when she realizes a lot of the other kids around her have special talents and skills that they've developed, including Gordo with his film making and Miranda with her violin. Meanwhile, Matt is scared after watching a horror movie and is convinced that their house is haunted.

Lizzie wants to be voted "best dressed" in her school and wants to buy an expensive pair of jeans. But her Mom refuses and insists on buying her clothes at discount store. Meanwhile, Matt has problems adjusting with his newly acquired fame because of his participation on The Uncle Wendel Show.

While Lizzie and Kate are stuck working together for the Spring Fling committee, Lizzie sees Kate knock over the bust of the school's founding principal. When Principal Tweedy (Phill Lewis) discovers this, he cancels the Spring Fling unless the person responsible comes forward. Kate keeps quiet so Lizzie decides to take the blame and is excluded from attending the fling. Lizzie is sitting at home sad, until everyone at school comes over to her house, as they decided to have the fling at her place, while Kate is left all alone at school. Meanwhile, Matt and Lanny have a hard time sharing a bike.

Lizzie begins mentoring a seventh-grader girl named Andie (Amy Castle), who begins to mimic her characteristics and behave like Lizzie. Initially flattered, Lizzie starts to dislike Andie and advises her to stop aping her blindly and be herself. Finally, Andie ends up being Kate's protege. Meanwhile, Matt must earn a merit patch with his Wilderness Cadets group, or he would be demoted. Sam tries to help, but ends up harming himself.

Frankie Muniz comes to town to shoot his new movie and befriends Lizzie. Lizzie and her friends learn a little about the pressures of teen stardom. Matt becomes Lizzie's secretary and tries to use his sister's fame for his own advantage.

Miranda has a misconceived notion that she is fat and begins to skip meals to look slim for a music video directed by Gordo. Miranda begins to develop an eating disorder and Lizzie and Gordo are concerned about it. However, in the end Lizzie convinces Miranda to be comfortable with her body and persuades her to stop dieting. Meanwhile, Matt shows a great artistic potential and his parents encourage him to pursue it. However, he gets into trouble when he trashes their house and uses their family car as canvas for his paintings.

Gordo skips a grade and gets promoted to high school. After initial euphoria, Lizzie and Miranda start to miss Gordo. Gordo too feels lonely at the high school but pretends to like it in front of Lizzie and Miranda. In the end, he returns to middle school. Meanwhile, Matt and Lanny plan to try out for the cheerleading squad at school but Sam feels that it's not a "manly" thing to do. Sam tries to lean away Matt from cheerleading by doing some "manly" things with him, but in the end he changes his mind and encourages Matt to try for cheerleading.

Kate is having a big birthday party and she invites everyone from her class including Lizzie, Miranda and Gordo. But Lizzie and Miranda's parents refuse to let them go to the party as there would be no adults around (and Kate's cousin Amy (Haylie Duff) doesn't make good chaperone material). So, Lizzie, Miranda and Gordo lie at their homes and go to the party anyway. But the party goes horribly wrong and Lizzie calls her mother for help. Eventually, all three are grounded for lying and going to the party anyway. Meanwhile, Matt and Sam are selected to star in a commercial for Cardio Punch Sports Drink.

A major food fight erupts in the cafeteria, and Lizzie, Kate and Larry stay after school to clean up the mess until someone confesses up to starting the fight. Matt and Lanny miss their bus while on a school field trip and end up wandering in the city all by themselves.

Lizzie's float for the Christmas parade gets a boost from a singing Santa (Steven Tyler).

Lizzie tries to get all eleven of her pictures in the school yearbook, but it would not be easy with Kate as the editor. So, Lizzie's family and friends hatch up a conspiracy to get the job done.

Lizzie starts an advice column on her school's website, but soon finds it difficult to handle when her good intentions backfire, especially when Gordo's liking her as more than a friend, is almost accidentally revealed to her. Meanwhile, Matt feels threatened by a new prankster in the class who is gaining more popularity than he is.

Lizzie's friends and family play a murder mystery party game at her house. Lizzie solves the mystery first but lets Gordo believe that he solved it first. In the end, Gordo is about to ask Lizzie out, but Sam interrupts and ruins their special moment.

Lizzie and her friends are graduating from middle school. They all sign each other's year books, except Gordo, who is unable to decide on what to write in Lizzie's book. He eventually writes something heartwarming and is rewarded by a kiss from Lizzie while posing for the class photograph. Meanwhile, Matt is unable to bear the summer heat at home, and thinks of various methods to keep himself cool.

All the kids at school are asked to put their hand prints on a wall, symbolizing unity. A water pipe bursts in a wall in Matt's room and to Lizzie's horror she'll have to share her room with her brother for a week until the repairs are done.

Parker, a girl that Gordo likes, turns down his offer to go with him to the school dance because of his height. Matt has to write a school report on his ancestors but he makes his report sound quite 'interesting'.

The McGuire family members (all except Lizzie) are all psyched about making their annual journey to Grubby Gulch, a "Wild West" theme park, after missing last year's trip. Lizzie, Miranda, and Gordo are reluctant to go for the trip, but Matt is very excited about it. Lizzie, Miranda and Gordo meet a boy and a girl respectively at the cafe, and arrange a date at the mall, but Lizzie's parents won't let them go, so they feign illness to go on the date.

Lizzie, Miranda and almost every girl in their class have a crush on their new English teacher, Mr. Keith, who is from Scotland. Meanwhile, Fredo the chimp comes to stay at the McGuire's home and Matt is not happy with it. With some intervention from Jo and Sam, soon Matt and Fredo are getting along very well.

Gordo's grandmother (Doris Roberts) now lives a more exciting lifestyle since the last time she and Gordo met. This irritates Gordo, but impresses Lizzie and Miranda. Meanwhile, Lizzie's parents feel ill and are confined to bed. Lizzie and Matt thus enjoy their unsupervised freedom at home.

Miranda is throwing a big house party, and refuses to invite Larry. Lizzie feels bad about it and decides to give him a makeover and sneak him into the party. Meanwhile, Matt and Melina make friends with an elderly couple as a part of a school project and find that the old couple are just like them.

Gordo receives a credit card by mail with a $5,000 line of credit and he uses it to direct a "big-budget" film. Matt is having problems finishing his school science project in time.

Lizzie feels uneasy, when her dad becomes best friends with Mr. Dig. Meanwhile, Matt is having a hard time with his mean teacher Miss Chapman.

After setting a new school record in gym and then beating Ethan Craft in arm-wrestling, Lizzie is invited to play touch football with the "cute guys". But Lizzie is worried when Ethan calls her a "dude", and she feels that she is losing her feminity by playing football. The gym teacher, Coach Kelly, reassures her, and also reveals that Ethan calls everybody a "dude". Unknown to Matt, Fredo the chimp completes his math homework, which gets him good grades in school and praise from his parents.

Kate sees Lizzie, Miranda, and Gordo at the audience of a kiddie TV program called Clover and Daisy's Magic Train, and teases them about it (in school). Meanwhile, Matt showcases his house as a 'Dust Museum', and shows the visitors around.