Diane Keaton (book “Saved”); Ellen welcomes back a couple who run a nonprofit that combats food insecurity on south side of Chicago.

Ellie Kemper; science guy Steve Spangler; Ellen welcomes back a man who broke his neck in a football game and became paralyzed, then committed himself to helping and inspiring others.

Zac Efron (“Firestarter”); Ellen and OneRepublic’s Ryan Tedder surprise a nurse who has been on the show five times; Bonnie Raitt performs.

Rebel Wilson (“Senior Year”); John Paul DeJoria, co-founder of Paul Mitchell; viral stars Sophia Grace and Rosie.

Seth Meyers (book “I’m Not Scared, You’re Scared”); Jerrod Carmichael (“Jerrod Carmichael: Rothaniel”); lifestyle expert Kym Douglas.

She’s got it handled — KERRY WASHINGTON is here! Kerry has shown her incomparable talents in numerous projects, from the small screen in “Scandal” to the big screen in “Ray.” The star will chat about her family and more! Then, country music superstar BRAD PAISLEY chats with Ellen! The accomplished musician has been topping the charts for years, and he’ll talk about his humble band beginnings, his family, and more!

The incredibly hilarious JULIA LOUIS-DREYFUS is here! With iconic shows like “Seinfeld” and “Veep,” she’s one of the most awarded actresses in TV history, with eight Emmys to her name. She’ll chat about being neighbors with Ellen and share her favorite moments from the show! Ellen welcomes her friend, former New Orleans Saints quarterback DREW BREES! The athlete and philanthropist will give an update on his family and share his advice to Ellen after retiring from the NFL.

Get ready “Mi Gente,” because J BALVIN is here! The global superstar was supposed to be a guest on the show the day the world shut down in 2020, so it’s only fitting he’s here during the last week of Ellen’s shows! Ellen also checks in with Oscar winner and new mom JENNIFER LAWRENCE! She’ll call her neighbor and talk about how Jennifer used to pretend to interview Ellen in her bathroom when she was a teen. Then, HOWIE MANDEL makes a surprise appearance!

The one and only OPRAH is here! The TV legend has her own unique view of wrapping a long-running, successful talk show, and she’ll share her advice and thoughts as Ellen nears the end of her own 19 season run. She’s one of Hollywood’s funniest and most entertaining stars… it’s MILA KUNIS! You know her from the films “Black Swan” and “Bad Moms,” and her work on the small screen in “That '70s Show” with her now-husband Ashton Kutcher. She’ll chat with Ellen about the end of her popular TV series, and her work helping her native Ukraine.

He’s one of the best-selling music artists of all time — BRUNO MARS is here! Ellen’s friend will take a look back at his iconic performances on the show over the years and talk about his Grammy-winning duo with Anderson .Paak, Silk Sonic! Then, Ellen has a surprise for The Lucky 13, a group of friends who all met on the show during Season 13. They have stayed in touch throughout the years, have been on the show together a handful of times, and have continued to give back to the community.

It’s Ellen’s final show, and she’s ending it with the first guest on her very first show, JENNIFER ANISTON. The two will look back at the Emmy-winning actress’ appearances over the years and will share how she dealt with the end of “Friends” after their 10-season run. Ellen will also welcome music superstar BILLIE EILISH! The recent Oscar winner will look back at making her daytime TV debut on “The Ellen Show,” and reflect on all she’s accomplished in the past few years. And finally, Ellen will chat with her friend P!NK. They’ll reminisce about her visits to the show and for the final music performance on the show, the multiple Grammy winner will take the stage with one of Ellen’s favorite songs, “What About Us.” You do not want to miss Ellen’s epic final show!