The new crop of "Real World" and "Road Rules" teams arrive in Las Vegas, in front of the Stratosphere Tower, where they are greeted by Road Rules: Latin America cast member Gladys Sanabria, who informs them that they will be competing for $100,000. Their first mission is to bungee jump from the Stratosphere Tower.

The cast are greeted by boxer Roy Jones Jr. and are told they would be given their next clue if they defeat him in the boxing ring. As it turns out, the "boxing" game is actually a toy game and despite losing, they still got their clue and are told to go to Tennessee. The teams are told that their next mission would be competing in a demolition derby. During the mission, a determined "Real World" team easily defeated the "Road Rules" team.

The teams are given their next clue. Los annoys some of his teammates for being cheap with his money. The teams head to a gym where they are taught by a teacher how to wrestle with each other. The teams head to The Palladium to compete against each other. The next mission is "Wheel of Wrestling", where a wheel determines the match-up. Los starts to feel isolated from the group and ends up leaving for a walk after getting into an argument with Piggy and Veronica over pizza.

Team morale is low for "Road Rules" and Los is still missing. Meanwhile, spirits are high for "Real World" as they begin to get cocky over their consecutive wins. The cast is paid a visit from Piggy's former castmate Kefla Hare and are told that they would be wrangling over 200 snakes for their next mission. In a mini challenge, the teammates are instructed to perform a series of tasks in order to win an additional $6,000.

Amaya's obnoxious personality begins to annoy some of her castmates. The teams are given their next clue and are informed that they would be competing in the Redneck Games.

The teams square off in "mud football." When Amaya sits out due to an injury, a miffed Heather cheers on Veronica, who's suffering from an injury herself. Also: Piggy fights with her boyfriend over the phone, then flirts with one of her coaches.

The teams compete in swamp-buggy races. Amaya's attitude, however, poses a problem for her teammates. Later, David swipes the "Road Rulers" horns in hopes of boosting the "Real World" camp's spirits.

The Real Worlders create an elaborate gag mission that keeps the Road Rulers out all night and leads to dissension between Veronica and Los.

The teams make homemade bikinis for this competition, but the pairing of Piggy and Los leads to further dissension within the "Road Rules" team, with Los accusing Piggy of attacking him off-camera.

The teams stay awake for 48 hours, confined inside windowless rooms where they have to keep a ball in continuous motion. While "locked up" together, the Road Rulers face their team problems, enabling Piggy and Los to forge an uneasy truce.

The teams perform accelerated - freefall parachute jumps onto a bull's eye, with the winning team receiving new cars.