Mike gets married and his bride is finally revealed will it be Katherine or Susan? Meanwhile, Lynette deals with the realities of being pregnant again; Bree works to break free from Orson; Gaby is tested by Carlos' niece who continues to stay with them; and a new family with dark secrets moves to Wisteria.

Mrs. McCluskey falls for a steak salesman called Roy Handler. Julie is found unconscious in the park bushes, which questions Mrs. McCluskey's decision to tell the police that she saw Angie Bolen's 19-year-old son, Danny, fighting with Julie.

A chance encounter reunites Gaby with her sexy ex-lover and gardener, John Rowland; Bree contemplates a weekend getaway with Karl; Lynette and Tom break the news to their kids that she's pregnant again; and Susan is convinced Angie's son is responsible for her daughter's attack.

Losing Mike takes its toll on Katherine. As Katherine unravels, Bree comes to her aid; Gaby grows weary of John’s intentions towards Ana with twins on the way, Lynette calls upon her family to step up around the house Susan learns Julie has been harboring some secrets and Angie throws a party for son, Danny.

When Juanita’s party is on the verge of being ruined after Gaby is deemed a bad mom, Gaby is determined to prove she’s a responsible parent. Bree gets defensive when she’s judged by a motel maid for having an affair with Karl. Lynette is put off by her new handyman when he defers to Tom for approval on all things and Susan and Katherine come to blows over Mike. Meanwhile, a lapse in judgment on Danny’s part leads to a terrible mishap that Angie and Nick must cover up.

Bree begins to fall for Karl and drifts further from Orson. Katherine continues her sad attempts at seducing Mike, as her conflict with Susan grows. Gaby gets Juanita expelled from school. Lynette learns Tom is cheating on his mid-term, and Angie hides the truth about her mother.

Susan believes that Katherine may be Julie's assailant. Angie invites reluctant Bree and Orson to dinner. Gaby struggles to home school Juanita. Lynette has her own suspicions about who attacked Julie. Angie confronts Nick.

Susan discovers a surprising connection between Mike and Katherine, which leads her to question her relationship with Mike. Meanwhile Gaby will stop at nothing to get Juanita into Catholic school, and Lynette's pregnancy becomes hysterically impossible to hide. Meanwhile, as Bree tries to hide her infidelity, Angie uncovers the truth about Orson and Bree's imperfect marriage.

In the wake of another attack, Angie decides the time has come for her and her family to leave Wisteria Lane; Bree and Susan are literally up in arms with one another as Bree's affair with Karl becomes increasingly difficult to hide; Lynette's pregnancy causes a rift with Gaby; and a confrontation between Mike and Katherine leads to a harmful and unexpected blow.

Gabrielle and Lynette's friendship is on the brink of collapse, whereas Bree and Orson come to an agreement about their marriage. Meanwhile, Susan hatches a plan to help an irrational Katherine, and Danny's vital mistake might cost Angie her freedom. In the meantime, Christmas cheer is curtailed when disaster strikes, as a plane crashes down on Wisteria Lane, putting lives in peril.

In the aftermath of the plane crash, the residents of Wisteria Lane think about what their lives might have been like had they made different choices. Susan contemplates a life with Karl had she not left him. Bree considers life without Orson. Lynette thinks about a future with her unborn twins. Carlos reflects on how Gaby would be as an over-protective mom and Angie ponders the consequences should her secrets be revealed.

Susan turns up the heat for Mike, Bree learns it won't be easy to undo the hurt she's caused Orson, Lynette discovers Tom's true intentions, and Gaby is forced to examine feelings she's suppressed about her heritage.

Lynette balks at the idea of seeing a couples' therapist. Meanwhile, Katherine is seeing her own psychiatrist, Gaby and Susan are determined to find out which of if their kids are in the smartest group at school, and Angie disapproves of Danny's new girlfriend.

Gaby and Angie challenge each other's parenting skills, Susan befriends a stripper and takes her under her wing, Lynette and Tom argue the merits of their new therapist, and a concerned Bree keeps a watchful eye on Orson for fear he may take his own life.

Former exotic dancer Robin will have a profound effect on Susan's friends with three teenage boys at home, Lynette will keep a watchful eye; Bree picks up a few tricks to engage Orson; Gaby looks for help with troublesome niece Ana; and Katherine will find a friendly companion.

Having never had the chicken pox herself, Gaby stays with Tuc and Bob and is reminded of what it's like to be single again; Lynette and Tom forget Penny's birthday; Bree hires a promising new employee; Susan cheats on Mrs. McKluskey; Katherine makes a surprising discovery and Angie grows concerned over Danny's disappearance.

While in the Big Apple, a chance encounter with supermodels Heidi Klum and Paulina Porizkova leads Gaby to an unexpected revelation about herself. Meanwhile, Lynette and Tom are in for a big surprise when Preston returns from Europe; Mike is determined to show Susan what a man he is after feeling emasculated; Bree discovers a shocking connection to her new employee, Sam; and Katherine is confused over her feelings for Robin.

Angie’s ex-boyfriend, Patrick, emerges after her trip to New York. Meanwhile it’s game on between Gaby and Susan, as they go to shameless lengths to top each other’s kids; Lynette believes there’s more to Preston’s fiancée than she’s letting on; Bree invites Sam over for a family dinner; and Katherine comes out of the closet.

Determined to derail son Preston's marriage to Irina, Lynette discovers the truth about her future daughter-in-law. In the meantime, Gabrielle offers to help out Bob and Lee in the most generous way, but does not consider the consequences. Bree begins to question whether Sam has a hidden agenda, and Susan gets creative to help Mike with his finances. Unbeknownst to Angie, Danny meets Patrick Logan for the very first time.

The Fairview strangler has been living among the women of Wisteria Lane. He once caught Gabrielle and Carlos in an intimate moment. Bree offered him a job and some dating advice. Susan encouraged his passion for art. Lynette will show him kindness and generosity. But... who is he?

Angie comes face to face with her ex, Patrick Logan, after years on the run. Meanwhile, Gaby and Susan plan an elaborate scheme against their husbands, Lynette sees a darker side of Eddie, and Bree meets a woman who knows Sam all too well.

Lynette comes to a shocking realization about Eddie. Meanwhile, Angie discreetly relies on Gaby for help when Patrick threatens the life of her son; Bree offers Sam a generous payoff to walk away; and Susan and Mike's financial woes result in the ultimate sacrifice.

Gaby risks her safety to help Angie; Lynette's fate and that of her unborn child lie in the hands of Eddie; Susan comes to grips with her financial woes; Bree considers confessing a secret she's harbored for years; and Angie must submit to Patrick's demands in order to protect her son.