Sheldon and Missy both run away from home. Mary gets upsetting news about George Sr.

Sheldon encourages Missy to question the Bible. Meemaw is determined to catch George Sr. in a lie. Mary helps Pastor Jeff search for a youth pastor.

Sheldon tries to convince Dr. Sturgis to return to the university. Also, Georgie upsets the family when he makes a life-changing decision.

Sheldon, Missy and Georgie adapt to new living arrangements. Meemaw opens a gambling room.

Sheldon and Dr. Linkletter struggle to solve an equation. Georgie has a solution for Meemaw’s business woes. George Sr. gives advice on Missy’s love life.

Missy asks some uncomfortable questions at church. Meemaw and Georgie go into business together.

Sheldon takes his first engineering class with Professor Boucher. Meemaw and Dale help take care of his ex-wife.

Sheldon battles President Hagemeyer’s mysterious boss over the university’s science requirements. Mary discovers that Georgie is working at Meemaw’s illegal gambling room.

Sheldon gets the science yips and has to learn how to not think. George plays handyman at Brenda Sparks’ house.

Sheldon gets a dorm room all to himself. Also, Meemaw gains an unwanted business partner.

Sheldon acts as Mary's spy during a youth lock-in at church. Also, Georgie is attracted to an older woman, Mandy.

Sheldon attends his first comic book convention. Also, Mary tries selling make-up.

Sheldon makes friends with his dorm neighbors. Also, George Sr. learns his job is in jeopardy.

Sheldon butts heads with Dr. Lee, a new scientist in the lab. Also, Mary is given a lotto ticket.

Sheldon joins Dr. Linkletter and Dr. Sturgis on a science road trip. Also, Georgie continues to lie about his age.

Meemaw's gambling room is a success, and Sheldon dips his toe in the stock market. Also, Missy starts a business.

Sheldon gets an odd request from an old friend, Paige. Also, George Sr. and Mary are caught in the middle of Meemaw and Dale's breakup, and Georgie comes clean to Mandy.

Sheldon copes with the death of a hero. Also, Missy wants to babysit, and Georgie struggles with his big secret.

George and Mary insist on meeting the new woman in Georgie’s life. Also, Sheldon and Missy have suspicions about what’s going on with their family.

Sheldon and Missy learn about Georgie’s pregnancy, and the whole family promises to keep it a secret.

As the church congregation gossips about Georgie, Missy stands up for her brother, and Sheldon is distracted by the family drama.

Sheldon struggles to cope with the first signs of puberty. Also, Mary and George Sr. hunt for new jobs, and Georgie and Meemaw take a business trip across the border.