Jesse is back home from the tour that he and the Rippers went on over the summer, and an ultrasound shows that Becky is carrying twins. While this thrills Becky, the same can't be said for Jesse, who feels afraid of what is now a double responsibility that awaits him.

After a talk with Teddy, Michelle realizes that she doesn't know how it feels to have a mother, so in order to have a mother, Michelle tries to find a woman for Danny. Jesse and Joey work together to try to come up with a tougher image for the band and D.J. is writing an essay for school, and it's titled "What it's like to be someone else". For this essay, D.J. temporarily switches places with Kimmy.

D.J. is absolutely fed up with Stephanie. Therefore, D.J. petitions the guys to let her have her own bedroom, she feels that after four years of sharing a bedroom with Stephanie she needs her own space.

Todd Mitchell, one of high school freshman D.J.'s schoolmates, is spreading a false rumor around school that D.J. is the worst kisser. It's his way of getting even with D.J. for refusing to let him kiss her on the way home from the library.

A record company tells Jesse that if he can write a song that can be a hit, Jesse and the Rippers will be signed.

Joey feels like his life is going nowhere, he doesn't want to read a bad review of his last performance, and he doesn't have to, because the newspaper's employees are on strike, and then he is offered the role of Ranger Joe on a tv show.

After school is dismissed for the day, D.J. goes to the Golden Gate Nursing Home to visit 75 year old Eddie Johnson, her "adopted grandparent" in the Adopt-a-grandparent program. At home, Stephanie and Kimmy have a disagreement.

Stephanie's dance teacher has told her that she has the potential to become a professional dancer. It would be a dream come true for Stephanie, but it means taking special classes before and after school and on weekends, an earlier bedtime, and less TV. As a result, Stephanie no longer has enough free time to spend with friends and family, and she has a dance recital coming up, and Danny is more excited about it than Stephanie is.

It's Michelle's 5th birthday. Michelle is afraid she's about to lose her status as "the baby of the family", because Becky is pregnant. Michelle thinks this status is what makes her special.

Michelle's birthday party has just started when Becky announces that she's going into labor. The twins are coming, and she needs to get to the hospital, fast. When Jesse leaves to take Becky to the hospital, the others stay behind to speed up Michelle's birthday party so they can get to the hospital to be there when the twins are born.

Becky and the twins come home from the hospital, and Becky's doctor has mentioned that it's common for new mothers to have mood swings. Nicky and Alex are still wearing their hospital bracelets. Michelle feels left out when D.J. and Stephanie are allowed to hold the twins and she’s not allowed to. Becky wants Nicky and Alex to be wearing the booties her mother made for them but Jesse doesn't think the booties are manly.

Danny introduces Vicky to the family, and Bay City magazine has chosen Danny as their bachelor of the month. When the issue that Danny is in is released, a lot of women start asking Danny out on dates and because of this he’s out virtually every night and Michelle misses her dad not being home to tuck her in at bedtime every night.

Michelle wants to learn how to ride her bicycle without the training wheels on it and Joey volunteers to teach her. During the bicycle lesson she crashes into a bush gets a scrape on her hand and blames Joey.

Danny, Jesse, and Joey are participating in a charity ice hockey game for KTMB TV. D.J. stays home to baby-sit Stephanie and Michelle. After they leave, Steve Peters, a boy from D.J.'s school, shows up to take D.J. to the movies. Problem is, Michelle has the sniffles and can’t leave the house while she has the cold and Stephanie needs to finish her book report. D.J., who desperately doesn’t want to miss out on a date with Steve so she decides to remedy this problem by taking Michelle and Stephanie to the movies with her and Steve.

It's time for Becky to return to "Wake Up, San Francisco", and Vicky has received an offer from a TV station in Chicago. Jesse, after yet another record company has rejected him, is now the only one who stays home with the kids while Danny, Becky, and Joey work at the TV station during the day, and Jesse's pride is hurting because Becky is the one who earns the money, while he is like a stay-at-home dad.

It's Stephanie's 10th birthday. When Stephanie hears that Tommy Page, her favorite singer, is scheduled to be a guest on "Wake Up, San Francisco", she begs Danny to invite Tommy to her birthday party, but Danny refuses. What Danny doesn't want Stephanie to know is that he has arranged for Tommy to be at the party and he wants to surprise her.

Stephanie has won a class spelling bee at school and she is now in the finals for best speller in the 4th grade. Stephanie's success in spelling makes Michelle want to learn how to read. At the 4th grade finals, the spelling bee ends up narrowed down to two students, Stephanie and the "Human Dictionary" Davey Chu.

Danny's sister Wendy has returned to the USA from the African country of Uganda. Wendy is a primate researcher and she has a pet chimpanzee named Ginger who quickly becomes attached to Jesse for some reason. Meanwhile a package has arrived in the mail, and when Stephanie and Michelle open it, it turns out to be a figure named "Nikata". The tag on it says that there will be a curse over the family if no one "feeds" Nikata.

After Jesse tells Michelle that she's not allowed to touch his musical instruments while he's not in the studio, she plays with them anyway, Danny grounds Michelle for the day, so she runs away to Teddy’s house.

D.J. now has her learner's permit and she's eager to learn how to drive, when Danny tries to teach D.J. how to drive, he makes her more nervous than she already is with the way he gives instructions, and by being overprotective so she goes to Jesse for lessons instead.

Danny arrives home from work, and notices that the girls are in a bad mood because they haven't had a good day. Neither has Joey, who would rather forget that day's "Ranger Joe" episode. Danny suggests that they take a little time off from this stress and go out as a family for "Tanner Family Fun Night". Jesse and Becky stay at home with Nicky and Alex.

It's time for Spring cleaning, one of Danny's favorite times of the year, but this year, Danny is overdoing it worse than ever. Everyone except for Danny gathers in D.J.'s bedroom for a meeting about this, and some hurtful things are said about Danny. What they don't know is that Danny is in D.J.'s closet installing shelf paper, and Danny overheard the whole meeting.

Jesse's recording studio is used by "The Funky Tongues", the hottest band in D.J.'s school. Jesse, Becky, Danny, and Joey then start preparing to go to a local awards ceremony where "Wake Up, San Francisco" and "Ranger Joe" have been nominated.

Aaron Bailey convinces Teddy to not play with girls anymore, and as a result, Teddy no longer wants to be Michelle's friend, so in order to win Teddy back, Michelle tries to look like a boy and act like a boy. Meanwhile, Jesse accepts an offer to appear on "Ranger Joe" as "Lumberjack Jess", and while Stephanie is listening in on a phone conversation between D.J. and Kimmy.

Michelle is the newest member of the local Honeybee troop, and Stephanie has "retired" from the troop because she is now too old to be in the troop. Because of budget cuts at the TV station, Jesse is fired from "The Ranger Joe Show", so Jesse decides to put his energy into his music.

Jesse is turned against the deal by the efforts to turn "Forever" into a dance song and turn Jesse into a dancer, until Fat Fish Records agrees to release "Forever" as the ballad Jesse wrote it to be, and a video for the song airs on MTV. Meanwhile, Kimmy needs to pass a Spanish exam before she can go to Barcelona with D.J., and Michelle tries to earn enough money to get an ant farm.