As Colorado Springs' Commissioner, Sully opposes a deal to mine for copper to make electricity. In order to sway Sully's decision, Mr. Garrick threatens Sully. Sully and Michaela's daughter, Katie, is kidnapped while the town celebrates Michaela's birthday. The search for Katie takes Sully, Michaela, and their friends on an adventure through Mexico that is filled with danger at every turn.

This final Dr Quinn episode is set 3 years after the end of the series. Dr. Mike and the family travel back to Boston to attend Colleen's graduation from Harvard Medical School. Colleen experiences the same prejudices as Dr. Mike, while Elizabeth Quinn is found to be seriously ill. Sully gets caught up in a land conspiracy while Brian finds a job with the Boston Globe. The series comes to a conclusion with a series of resolutions and a touching finale.