Dr. Mike and Sully return from their honeymoon and begin unpacking at their new homestead. A Boston banker comes to town and stirs up controversy among the townspeople as the inevitability of progress ensues.

Loren convinces the town to pay a baseball team to visit for an exhibition game against the town's team. The two teams will share the ticket sales, but problems arise when it's discovered Loren didn't read the fine print.

As Dr. Mike becomes increasingly absorbed in her romantic life with Sully, Colleen, feeling rebellious, joins her school friends in dangerous and questionable escapades. When Brian also begins to feel ignored, Mike and Sully realize how important it is to balance their new life.

Brian's dog Pup gets bitten by a rabid raccoon. Then Matthew's fiancée gives the dog water. She also gets bitten.

Elderly Abner Foley comes to town looking for alternative treatment and a very friendly dog adopts Jake Slicker. The rest of the town looks forward to the costume party but first Brian must face a very big fear.

Dorothy gets her book about the town published, but the townsfolk read her depiction of them differently than she intended.

Sully's best friend asks him to come to Nevada to help him. Loren suffers a stroke and Dr. Mike believes that he can recover if he works at it, but Loren's negative attitude prevents any progress.

Dr. Mike intends to climb up Pike's Peak as part of a birthday celebration to the derision of the men. Grace, Dorothy, and Myra decide to join her. Jake and Preston plan a casino with the doctor away.

Dr. Mike injures herself after the other women have turned back on their quest to climb Pike's Peak. Sully steps in for his wife on the council to thwart Jake and Preston's casino plans. Grace, Myra, and Dorothy change their minds and head back up the mountain.

As the community prepares to celebrate Thanksgiving, Dr. Mike and Sully become anxious with their inability to conceive. As the couple try to get used to the idea of not having a baby, Jake becomes depressed about being alone.

Rushing to the railroad camp to battle an epidemic, Dr. Mike & Sully are shocked to find Matthew, heartbroken over the recent death of his fiancée, running the saloon there.

Dr. Mike and her family receive an unexpected gift from Boston, a small poodle unsuited to life on the frontier. Brian has his first crush on Sara, Preston is embarrassed by a painful kidney stone, and the Pastor plans a living nativity.

An young orphan boy is taken in by Grace and Robert E. begins to show symptoms of an unknown health problem.

As the town grows, a rowdier element is evident and the citizenry wants a little more law and order. Matthew believes he is suited for the job of sheriff but refuses to carry a gun which worries Dr. Mike.

After a long period of grieving over his lost fiancée, Matthew finally finds love again, but the object of his affection works at Hank's saloon.

When a charlatan passes through town selling shares in a nonexistent invention, nearly everyone in Colorado Springs buys into the scam.

When a politician's son is kidnapped by a fierce, legendary mountain man, Sully must lead a rescue party to the remote site where a highly unusual ransom is to be paid.

When Ezra Leonard offers a $1000 reward to the capture-dead or alive- of the mountain man who kidnapped his son, Sully's rescue party turns into an unruly mob. Dr. Mike must accept help from Dr. Cassidy to save her pregnancy.

News from his former mentor's upcoming visit has the Reverend Johnson rushing to ensure he makes a good impression. He quickly attempts to raise enough money to fix up his dilapidated church.

When a stranger is convicted of raping a young girl and murdering an old man, he is sentenced to death. Some people are conflicted about whether or not it is right to take "an eye for an eye".

Even though Dr. Mike and the Reverend Johnson favor the opening of a Indian school on the reservation, Cloud Dancing sees it as the final destruction of Indian culture.

Dr. Mike's dearest friend from college comes to visit her in Colorado Springs, both women are initially happy to see one another, but soon resort to their competitive relationship of years past.

Dr. Mike is nominated for Colorado's Woman of the Year and the town regales the judge with her accomplishments. Hank's Nana comes to visit and he "borrows" Myra and Samantha to pose as his family.

Dr. Mike, nearing her pregnancy's end, has her plans for scaling back interrupted when Cloud Dancing is stabbed and Emma needs an operation. Matthew wants Emma to leave Hank's employment when she's better.

Isabelle Maynard, an attractive painter, arrives in town attracting the eligible bachelors particularly Preston. But after the citizens learn Isabelle has leprosy they are determined to drive her out of town over Dr. Mike's objections.

A young brave kills a soldier in self defense, but Cloud Dancing confesses to it to protect him. Dr. Mike and Sully defend Cloud Dancing during his trial for murder.

Dr. Mike's mother and sisters arrive with a young Dr. Cook to deliver the baby. Conflict arises between Horace and Myra which ruins Preston's hotel groundbreaking. Sully works to prevent Cloud Dancing's transfer to another reservation.

Dr. Mike leaves in the night to treat Sully, who was wounded while helping Cloud Dancing. She goes into labor with only Sully to assist her.