A case involving the murder of a petty officer, who is a former gang member and later mentored by agent Pride, is investigated. Meanwhile, agent Brody is still trying to get acquainted with New Orleans and doctor Donald "Ducky" Mallard also offers some insight.

NCIS Special Agent Tony DiNozzo assists the New Orleans team when a Navy lieutenant on liberty dies of the bubonic plague. The team races to locate all additional sailors on liberty, control a potential outbreak and determine the source of the highly infectious disease.

The NCIS team investigates the crash of an armored transport bus carrying Naval brig detainees after four prisoners escape, including a black market broker who is one of the country's biggest national security threats. Meanwhile, Pride turns to Gibbs for assistance when a case file needed for the investigation is full of redactions.

After a Navy SEAL is found murdered in a sorority house, the NCIS team must determine if the motive pertained to one of his classified missions or collegiate foul play. Meanwhile, Pride's daughter, Laurel, pays the NCIS office a visit.

The NCIS team is given a 22-hour deadline after the murder investigation of a Chief Warrant Officer who specialized in counterintelligence reveals his wife had been kidnapped and is being held for ransom. Meanwhile, Senior FBI Agent Fornell travels to the Big Easy to assist with the case.

With New Orleans decorated for Halloween, the NCIS team investigates the murder of a Naval Staff Judge Advocate found in a cemetery dressed in a Victorian costume with vampiric puncture wounds on her neck. Meanwhile, the team debates what Halloween night activity and costumes would be best.

The NCIS team investigates the murder of a Navy Officer with the highest level top secret clearance who was recently assigned as a tech liaison with a private developer. Also, Pride transforms the carport into an auto shop as he works on the first car he ever gave his wife.

The NCIS team investigates the murder of a Petty Officer found in a Mardi Gras float storage facility with an engagement ring and proposal plan in hand. However, the case takes a mysterious turn when the team is unable to locate his supposed long-term girlfriend.

After a stolen Navy-issued gun is found to belong to a Chief Petty Officer who died 40 years ago, the NCIS team reopens the cold case, one that Wade has personally tracked and investigated for years. Also, the team prepares for their annual Thanksgiving dinner together.

The NCIS team investigates the murder of a retired SEAL who tracked down individuals impersonating military personnel. But the case takes a mysterious turn when the lead suspect is found with the Navy-issued jacket of an officer believed to have been killed in the line of duty in Afghanistan. Also, Brody discovers the normally holiday-obsessed Lasalle is inexplicably unenthusiastic about Christmas.

The NCIS team investigates a deadly explosion at the Navy-Marine Corps Relief Gala, and discover Pride was the intended target of the bomb.

When a Navy Admiral’s daughter is the prime suspect in a double murder case aboard a research boat, the NCIS team partners with the Coast Guard Investigative Service (CGIS) to work the case. Meanwhile, Lasalle tracks down his estranged brother.

A Navy Lieutenant Commander in impeccable shape turns to Pride and the NCIS team to solve his imminent murder after discovering he has been poisoned with a lethal dose of radiation.

After an NCIS agent is killed during a security detail for the Vice Chief of Naval Operations, the team must determine if this was an assassination attempt or if someone is targeting one of their own. Meanwhile, Agent Brody is placed under investigation and her mysterious past is reevaluated.

After a Petty Officer is found murdered in the midst of Mardi Gras events, the NCIS team investigates what parades and parties led to his untimely death. Also, Pride must decide what aspects of his strained relationship with his father he is willing to share with his daughter.

After a Navy recruiter is the target of a lethal hit and run, the NCIS team investigates whether the murder was tied to her career or her role as a foster mother to two brothers. Also, Lasalle grows increasingly concerned for his brother’s welfare after welcoming him into his home.

Pride is adamant the elusive “Baitfish” has returned and, in attempt to locate his nemesis, he has the team investigate crime scenes and chase leads from New Orleans to Charleston, SC.

After a sailor is murdered in the champagne room of a strip club, the NCIS team links the murder weapon to two additional unsolved cases and discovers that the names of all three victims appear on a mural in a dilapidated part of town. Also, Brody’s ex-fiancé pays her a surprise visit.

While conducting an autopsy on a Petty Officer who is believed to have died from natural causes, an armed man enters the morgue and holds Wade, Sebastian and Danny hostage.

When a Navy Commander’s car is stolen with his baby inside, the NCIS team must determine if this was a random carjacking or a targeted abduction.

With no memory of the night before, Lasalle’s brother, Cade, turns to NCIS for help when he finds his girlfriend’s body in the trunk of his car. Despite a mountain of evidence that implicates Cade, and the case being under Captain Jim Messier and Jefferson Parish jurisdiction, Lasalle is determined to prove his brother’s innocence.

To send a message to Pride, Baitfish murders someone close to the NCIS team, prompting a citywide manhunt for the elusive criminal.

Pride suspects a mole among the ranks as NCIS and local law enforcement continue to track the Broussard Syndicate after new intelligence suggests a breach at the ports.