As New Orleans grapples with the effects of COVID-19, Pride sends Tammy and Carter to investigate a suspicious death aboard a humanitarian ship offshore, where they learn that some crew members are infected with the deadly disease. Also, Wade is overwhelmed by the high volume in the morgue due to COVID-19.

As Tammy and Carter continue to investigate the suspicious death aboard a COVID-infected humanitarian ship offshore, Pride and the team discover that the PPE they were sent to distribute may hold the key to finding the killer. Also, Rita returns to New Orleans to surprise Pride, Wade helps a grieving woman who can't find her brother who died from COVID-19, and Patton and his goddaughter get into a heated argument.

When an NOPD officer is murdered, Pride and the NCIS team take on a group of dirty cops when they discover that the victim was also a key witness in multiple excessive force cases. Also, Tammy faces the reality of being in a new relationship.

As the NCIS team continue to investigate the murder of an officer who was about to whistle blow on police misconduct within NOPD, Pride must get creative in order to finally get rid of the dirty cops. Also, the Mayor asks Pride to join her new task force to address systemic issues plaguing their city and, as Covid continues to overwhelm the system, Wade finally addresses the toll it's taken on her.

As NCIS investigates a suspicious death and the missing key piece of evidence is a top secret, high tech battery, Pride and the team realize there could be deadly consequences if it falls into the wrong hands.

When a torpedo hits a fishing trawler at sea, the entire Gulf Coast is in jeopardy as Pride and NCIS race to find the submarine before it can strike again.

When a Navy therapist with a high level of security clearance is murdered, Pride and the team discover that she was working around the system to get justice for victims of sexual assault. Carter's mother confronts him when he refuses to talk to the FBI for a background check on her behalf. Sebastian starts to form a bond with a key witness who was hit hard by the COVID-19 pandemic.

As Pride and the team continue the investigation of an Officer’s assault and the murder of her therapist, NCIS zeroes in on a prime suspect who’s been working the system for years. Also, Carter and his mother talk about how they’ll move forward after a past mistake, and Sebastian begins a promising new relationship.

Pride and the team are on the hunt for a kidnapped 14-year-old and discover that her father, who will soon have custody of her, is a radical survivalist living off the grid.

When a Petty Officer is shot down by a sniper, Pride and NCIS hunt down the killer, only to find that he may not be acting alone. Rita tells Pride that she has been offered a compelling job…in Kansas City.

Sebastian’s life is in danger when a criminal he put behind bars escapes police custody. Carter is tasked with keeping Sebastian in protective custody. Carter and Hannah’s flirtation is fun gossip fodder for Tammy and Sebastian.

After a Molotov cocktail is hurled into Pride’s bar, evidence leads him directly to an old nemesis who has been keeping a secret that will affect his life forever. Tammy uses her profiling skills on Hannah and Carter with shocking accuracy.

The team investigates the deadly bar bombing and impending criminal turf war involving Sasha Broussard. Also, while Pride must come to terms with having Connor in his life, Carter and Hannah work to define their new relationship.

As Pride directs the team to link Sasha to the recent attacks in New Orleans, he must help Connor come to terms with who his mother really is. Also, Carter and Tammy search for a stolen highly trained military dog, and Pride and Rita make an important decision about their wedding.

While Pride and Rita plan their wedding, the FBI arrests Connor in connection to the bar's firebombing as a means of getting to his mother, Sasha Broussard, and Rita may be the only person who can save them.

On the eve of Pride's wedding to Rita, and Connor entering witness protection, Pride must find who attacked Jimmy and Connor, while also figuring out Sasha's ulterior motives regarding their son.