Andrea Canning reports on a young, beloved woman who is found dead near a soccer field in Indiana. Detectives try to piece together a puzzle that leads them to the most unexpected of suspects.

When a beloved teacher and former beauty queen goes missing in Georgia, it triggers a decade-long investigation that makes national headlines. Andrea Canning reports.

A pilot flees after a deadly plane crash, and becomes a fugitive living a double life for decades. He tells his story for the first time to Keith Morrison.

The sister of a man who died after robbing a bank when a bomb that was placed around his neck detonated talks about the case.

A young woman’s murder remains unsolved until someone comes forward to reveal her own harrowing story. Keith Morrison reports.

The parents of missing South Carolina woman Heather Elvis, Debbi and Terry Elvis, open up to NBC News’ Andrea Canning about the search for their daughter.

The mysterious deaths of 6-year-old Max Shacknai and 32-year-old Rebecca Zahau, who died within days of each other in 2011 at a California beachside mansion

When a mother is discovered dead inside her home, it appears to be a suicide. But when investigators start to interview those closest to her, an evil plot emerges. Dennis Murphy reports.

A soon-to-be bride is caught in the middle of a twisted murder plot that has detectives questioning if she played a role in it.

The mysterious death of a 23-year-old mother in New Mexico goes unsolved, and her family searches for answers. Keith Morrison reports.

When a creative entrepreneur abruptly leaves his business for an international surfing adventure, his family’s worry turns into suspicion. Keith Morrison reports.

When a hard-charging boss in Arizona is shot to death, police uncover a complex web of bruised egos in his professional life and a trail of broken hearts in his personal life.

The homicide of private first class soldier and young mother Karlyn Ramirez; a glimpse into the FBI's crime lab and an in-depth look at how multiple agencies uncovered a plot that spanned several states and prompted suspicions of espionage.

Interviews with former journalist Amanda Lindhout and the undercover agent who spearheaded the international manhunt for the individual responsible for her 2008 kidnapping and torture in Somalia.

An in-depth look at the history of allegations against singer R. Kelly, including interviews with several women who accuse Kelly of misconduct.

A mother of two mysteriously vanishes from her parents' Michigan home while going to check the mailbox, leaving her phone and identification behind; police declare her dead without discovering a body.

Looking back at O.J. Simpson's infamous Bronco car chase and subsequent standoff with the LAPD SWAT team, 25 years after the murders of Nicole Brown Simpson and Ron Goldman.

A teenager is convicted of encouraging her boyfriend to kill himself; exclusive interviews with those on both sides of the case.

Dennis Murphy speaks to a Georgia father accused of murdering his ex-wife. While his friends work to prove his innocence, prosecutors count on his children to testify against their own father.

A man disappears after a duck hunting trip in Florida on his sixth wedding anniversary and is later found to have been murdered.

The investigation into a woman's mysterious disappearance from inside her home in Washington, D.C., reveals a connection to the decades-old disappearance of another woman.

Police forced entry into Kelsey’s home. She was nowhere to be found…

Andrea Canning reports on the murder of Shele Danishefsky, a wealthy New York City finance executive whose 2009 death was originally ruled accidental.

A young woman finds out her boyfriend might have killed a college football player out of revenge. She struggles with going to officials, fearing she could lose her life. Keith Morrison reports.

When Ohio mother Heather Bogle goes missing, a detective identifies multiple suspects, until he himself comes under scrutiny for his investigation. Josh Mankiewicz report

Two young girls in Washington are snatched in broad daylight. The case goes unsolved until a new detective tries to solve the mystery that haunted her childhood. Keith Morrison reports

When a young woman fails to show up to work, her mother rushes to try to find her. What she discovers begins an investigation that leads to a suspect no one imagined. Keith Morrison reports.

An Alabama father calls police after his son throws a house party. Just 11 minutes after a deputy leaves his house, another 911 call is placed. What happened? Josh Mankiewicz reports.

A Pennsylvania mother disappears from work one summer day. The case remains cold despite 60 investigators trying to crack it. Could the 61st detective solve the case? Josh Mankiewicz reports

When a dancer is murdered in her Virginia home, investigators are hopeful they can crack the case. Could an unexpected tip lead them to an unlikely person? Andrea Canning reports.

The murder of a young schoolteacher in Pennsylvania goes unsolved for years, but investigators discover a new tool that may finally help unlock the murderer's identity.

Two young women are shot and left for dead on a beach in Texas. After one survives, she is determined to find out who the attacker is. Could the wrong man be in prison? Josh Mankiewicz reports.

A University of Utah athlete is found murdered on campus. She had reached out to campus police for help multiple times before her death. Could it have been prevented? Josh Mankiewicz reports.

When Shirley Carter is gunned down in her kitchen in rural Iowa, the whole town is stunned. But when police and her family are left with no leads, Shirley’s husband does something even more shocking -- he points the finger at their son. Dennis Murphy reports on the major developments in the case, and the family feud that led to a murder trial.

A successful business woman and mother of three is found shot in her office. Will justice be served? Keith Morrison reports.

A missing mother in Florida leaves behind a three-year-old son, whose memory of their last night together offers some clues as to what happened to her. Dennis Murphy reports.

College senior Reagan Tokes was just months away from graduation when she was shot and killed in a public park. Her parents’ heartbreak soon turned to outrage. Andrea Canning reports.

A Kentucky man is convicted of murdering his co-worker; the mystery is considered solved until a stunning disclosure, years later, turns the closed case upside down.

Her son died under questionable circumstances and a mother is demanding answers from the university he attended (High Point), the frat house he pledged with (Delta Sigma Phi) and the people he considered friends.

A 59-year-old father is found dead in his home, and family members assume it is related to his ongoing health issues. But when the coroner reveals he didn't die of natural causes, police begin an investigation questioning some of his family members.

Cornell student and star athlete Charlie Tan excels in everything, except when he gets caught in the middle of a murder investigation. The community is left in shock. Dennis Murphy reports.

A divorced, bi-sexual Texan mother of two, with a new man in her life, goes missing as Hurricane Harvey approaches. Both cooperative, the missing mom's ex-husband, and new boyfriend, fail their polygraphs.

A San Diego woman arrives at an emergency room, near death. Doctors, the FBI and local law enforcement must solve not only a medical mystery, but also a horrific crime. Natalie Morales reports.

Pamela Smart was television's first true crime fascination after her husband was found murdered. Police discovered that Pamela Smart was keeping a big secret. Andrea Canning reports.

When a college student is found dead after a party, his mother is determined to try to find out what happened. Dennis Murphy reports on the unexpected twist that no one saw coming.

A wife calls 911 to report her husband has been shot on a country road in Texas. Could the dramatic police footage from the scene end up being key in the investigation? Josh Mankiewicz reports.

Rarely-seen video is revealed of Robert Durst’s friends testifying for the prosecution as to why he might have killed his best friend, Susan Berman. Keith Morrison reports.

Recently uncovered pages from the diary of John Hinckley Jr, written after his arrest for the attempted assassination of President Ronald Reagan, are revealed. Troy Roberts reports.

Lester Holt spends two nights embedded inside the largest maximum security prison in America, the notorious Louisiana State Penitentiary, also known as Angola.

The latest detail on the case of missing New Canaan mother of five, Jennifer Dulos. Dennis Murphy reports.

When a college student vanishes from a park in Salt Lake City, her friends are dedicated to finding answers. Keith Morrison reports on the search that made national headlines.

Savannah Guthrie speaks with six of Jeffrey Epstein's victims.