A triple murder divides a small town in Kentucky. As secrets come tumbling out, residents begin to wonder: How well do we really know our neighbors? Keith Morrison reports.

A family’s search for answers in the 2014 disappearance of 28-year-old Fayetteville, North Carolina construction worker James Chambers. Andrea Canning reports.

A man goes overboard on a romantic sunrise cruise with his wife on Lake Coeur d'Alene in Idaho. Investigators begin to think his death may not have been an accident. Keith Morrison reports.

Family members and investigators speak out for the first time on network television since the death of “Love Has Won” spiritual leader Amy Carlson, known to her followers as “Mother God.” The case gained worldwide attention after deputies found her mummified body covered with Christmas lights in a Colorado house where members of the group stayed.

After a 27-year-old woman is found murdered in her Michigan home, investigators quickly identify a person of interest, but years pass without an arrest. Andrea Canning reports.

Josh Mankiewicz reports the latest developments following an arrest in the Kristin Smart case; Craig Melvin reports on the mysteries surrounding the powerful Murdaugh family of South Carolina.

Investigators desperately search for a killer after Florida teacher Denise Hallowell is found murdered. Dennis Murphy reports.

New evidence, exclusive interviews, and an in-depth look at Lori Vallow and Chad Daybell, the Idaho couple charged in the murders of Lori’s children JJ & Tylee. Keith Morrison reports.

Convicted murderer Drew Peterson speaks out about the murder of his third wife and the disappearance of his fourth wife in his first network TV interview in more than a decade; insiders close to the case speak out, including Stacy Peterson's sister.

New details expose how the Gucci family was undone by jealousy, backstabbing, and, ultimately, an act of murder; insiders, close to the fashion empire, speak out for the first time on network TV about the murder of a prominent family member;

An investigation into allegations against fashion mogul Peter Nygard, accused of sex trafficking dozens of women over several decades, reveals new details in the case. Natalie Morales reports.

A chance encounter on the Pacific Coast Highway with a woman he first spoke to in a jail cell leads Keith Morrison to reexamine the mysterious death of Las Vegas casino magnate Ted Binion.

A Connecticut mother speaks out about her fight to keep her assailant from walking free.

Fort Worth, Texas, investigators desperately search for answers after a 17-year-old high school student is kidnapped and murdered following a Valentine’s Day dance. Josh Mankiewicz reports.

When a Colorado mother vanishes on Mother’s Day in 2020, investigators are left with minimal clues until a recording device exposes a potential motive. Keith Morrison reports.

When a snake breeder is found dead, first responders initially believe his missing anaconda could be to blame. But the investigation reveals a sinister betrayal. Andrea Canning reports.

A mystery in paradise unfolds when Sarm Heslop vanishes from her boyfriend's luxury yacht in the U.S. Virgin Islands; new details emerge on the case that made international headlines and left investigators with more questions than answers.

Detectives in Washington D.C. discover a puzzling connection between two women who disappeared two decades apart; an investigation reveals a sinister secret hidden along one of the busiest stretches of interstate in the country.

A family gathering ends with one man dead, leading to more than a decade of questions — was it suicide or murder? Keith Morrison reports on the latest twist in the case.

New details emerge in an alleged murder-for-hire plot targeting a former NYC cop's husband.

When former Arkansas State Senator Linda Collins is found fatally stabbed outside her home, detectives investigate if her murder is connected to her political career or her personal life; the victim's children speak out about the case

New interviews reveal the latest twists and turns in the case of Pam Hupp, charged in the murder of her close friend Betsy Faria; Betsy's daughter, as well as the prosecutor behind the wrongful conviction of Betsy's husband speak out.

In 2016, 22 days after Sherri Papini vanished from her home, she reappeared, claiming she’d been kidnapped. The detectives who cracked the case discuss the details with Keith Morrison.

After New Jersey mother Michelle Lodzinski reports that her 5-year-old son has vanished from a carnival, detectives embark on a decades-long investigation until a family member identifies a key piece of evidence pointing to a potential suspect.

After a woman is stabbed to death in her home, investigators uncover personal details that point to multiple suspects and possible motives. Josh Mankiewicz reports.

After a prominent plastic surgeon is murdered in his Asheville, North Carolina home, investigators uncover a trail of clues pointing to an unlikely killer. Keith Morrison reports.

Insiders speak out about the latest developments in the suspicious death of a New York woman.

When 18-year-old Anjelica Hadsell disappears, the investigation uncovers a sinister betrayal.

After a Portland, Oregon chef is murdered in his kitchen at work, investigators uncover a potential clue written years earlier. Josh Mankiewicz reports.

Amber Heard sits down with NBC News’ Savannah Guthrie in her first interview since the defamation trial brought by her ex-husband Johnny Depp.

When 19-year-old Anton Black dies while being taken into police custody, the community seeks justice; a yearlong "Dateline" investigation looks at the officer at the center of the case and missed warning signs.