When a Colorado rancher mysteriously disappears, his friends know something isn’t right and spend years fighting for answers. Josh Mankiewicz reports.

A young woman survives a brutal attack and detectives work tirelessly to find a suspect. But when they finally do, the victim is convinced they have the wrong man. Keith Morrison reports.

Dennis Murphy has the latest on the case of a Florida law professor murdered in his garage, including new details, newly-released evidence and bombshell testimony from a long-awaited trial.

When a doctor is found murdered, investigators are stumped as to who would want him dead. Police discover simmering jealousies and a love triangle. Andrea Canning has the latest developments.

THE STORY: When LaJoya McCoy, a mother of two, suddenly goes missing, police arrive to find a crime scene at her apartment. As detectives investigate, her friends and family reveal LaJoya feared she was being stalked. REPORTED BY: Josh Mankiewicz WHERE: Monrovia, California

Josh Mankiewicz reports on the mysterious disappearance of Carole Baskin’s husband, Don Lewis, who vanished in 1997 while preparing for a trip to Costa Rica

A new look at The client. Beverly Carter, a top-selling realtor from Little Rock, Arkansas, goes missing after showing a house. When her friends receive mysterious text messages from Beverly, they know something isn’t right. What could have happened?

When 21-year-old college student Helene Pruszynski is found murdered, the case remains cold for nearly forty years until a new detective uses an innovative method to catch Helene’s killer.

In Morris, Alabama, faith is a way of life. But when a man is murdered, rumors involving a pastor begin to swirl and the truth ends up turning the community upside down. Andrea Canning reports.

When a woman dies after what appears to be an accidental fall in the shower, two friends join forces to seek justice on her behalf. Andrea Canning reports.

After Ellie Green doesn't hear from her mother for a few days following an argument, she begins to worry. Then she learns her mother is dead. But is that the truth? Keith Morrison reports.

When pediatric dentist Kendra Hatcher is found dead in Dallas, Texas, police uncover a complex plot that leads them on an international manhunt. Keith Morrison reports.

When soldier Vanessa Guillen vanishes from Fort Hood, her family works to bring attention to her disappearance. Vanessa’s case inspires a movement across the country. Andrea Canning reports.

After Todd Chance is murdered, police follow a trail of video evidence as they work to track down his killer. Andrea Canning reports.

As COVID-19 cases surge across the country, Lester Holt takes a comprehensive look at the latest plans to get a vaccine into the hands of Americans.

A woman is shot to death in her bed while her husband and daughter are home. When police rule out robbery, they are left wondering who would want to kill Jan? Keith Morrison reports.

Soon after 23-year-old Kaylee Sawyer disappears following a night out, an intense multi-state manhunt leads police to find a killer. In this follow-up to the episode which aired on April 27, 2018, Keith Morrison reports on the latest updates in the case.

When an Eastlake, Ohio resident is offered $50,000 to kill someone, he calls the police. Acting quickly, investigators set up an elaborate sting operation. Andrea Canning reports.

New insights into the real story of the very private royal, including a look at Diana's troubled marriage, her turbulent life in the royal family and the investigation into her death.

Craig Melvin speaks with the families of George Floyd, Jacob Blake and Eric Garner about police brutality, racial injustice and a shared commitment to turn their pain into advocacy work.

A romantic cruise intended to rekindle love between Micki and her ex-husband turns to tragedy when Micki vanishes. The investigation leads to secret recordings and a surprising star witness.

Andrea Canning speaks with U.S. District Court Judge Esther Salas about the deadly shooting at her home in 2020 that killed her son Daniel and critically injured her husband Mark.

Keith Morrison has the latest developments in the case of a 21-year-old UCLA student, whose body was found in an infamous Los Angeles area train tunnel in 1990.

When a University of Utah athlete is found murdered on campus, investigators learn that she had reached out to the campus police for help multiple times before her death.

A nationwide manhunt is launched after a woman dubbed the “killer grandma” goes on the run through the Gulf Coast. Dennis Murphy reports.

A college student goes missing in broad daylight from her off-campus job. As police begin to investigate, they receive a mysterious phone call that changes everything

Popular basketball player Lorenzen Wright is found murdered in 2010. His mother insists she knows who murdered her son and is relentless in her pursuit of justice. Andrea Canning reports.

When the owner of a school promoted as a place to help troubled girls is accused of abusing students, his daughter must decide whose side she’s on. Keith Morrison reports.

When Susan Woods doesn’t show up for work, she is soon discovered dead in her bathtub. As police search for answers, they find a trail of victims. Natalie Morales reports.

Former NXIVM member Dr. Danielle Roberts defends branding members of the alleged sex cult; former members India Oxenberg and her mother, Catherine, open up about how they are doing after the group's founder is convicted of felonies.

Witnesses see a woman handcuffed in a parking lot and taken into an unmarked car by a blond woman. But detectives can't find any record of an arrest. Where could she be? Josh Mankiewicz reports.

Amateur internet investigators, new DNA technology and a dogged investigator help police find a killer – and identify a victim for years known only as "Lavender Doe."

Lead detectives in the murder investigation of University of Utah student MacKenzie Lueck speak exclusively to Keith Morrison about the case that made national headlines.

Exclusive new interviews and details on the deaths surrounding Chad and Lori Vallow Daybell, a case Keith Morrison has been on since it drew national attention after Lori’s children disappeared.

When a woman is murdered, a web of sex and lies is uncovered, revealing a prominent family’s dark secrets. Detectives and an FBI informant tell Dennis Murphy about the case for the first time. Update of Secrets in the Suburbs, S20E45.

When Kathleen Schroll makes a phone call that names her killer right before her death, it leads to the arrest of a father for murder, but after two trials and 12 years, authorities begin to wonder if he was the victim.

When a private investigator and former police officer vanishes, detectives think there may be more to the story when strange text messages start to appear... Keith Morrison reports.

After filming wraps on an indie horror film, the cast and crew learn their killer star isn’t who she says she is. It’s a plot twist that reveals a real-life killer. Keith Morrison reports.

A Michigan community is shocked when a local mother is found stabbed to death. After the case goes cold for more than a decade, a bombshell reignites the investigation. Andrea Canning reports.

A wealthy surgeon’s whereabouts remain unknown for years after he disappears on vacation in Greece, leaving behind his wife, financial ruin and mounting malpractice suits. Rob Stafford reports. UPDATE to 1956 - The Great Escape

A mother of two vanishes, and nearly two years later her body is found in the San Diego Bay, but medical examiners say she had only been dead for about a month or two. Keith Morrison reports.

When a Kansas prisoner escapes in a van driven by a wife and mother who volunteers at the prison, investigators scramble to track down the pair. Andrea Canning reports.

A mother's search for answers in her son’s murder raises questions about whether Chicago police detectives did enough to try to solve his case. Josh Mankiewicz reports.

After a mother and son are found dead, it takes nearly a decade to unravel the case. Andrea Canning reports the latest, including how a second investigation led to a new and unexpected arrest.

After a nightclub owner is gunned down in his home, Chicago police discover the death was a targeted killing, connected to a twisted sense of loyalty and tradition. Natalie Morales reports.

Lester Holt reports on how the investigation into the murder of four-year-old Barbara Jean Horn revealed decades of misconduct across Philadelphia’s criminal justice system.

A woman who helps solve cases searches for her missing niece and pushes for change as part of the growing movement to save missing and murdered Indigenous women. Andrea Canning reports.

Lester Holt interviews family members, including the now-grown children of some of the passengers and crew of Flight 93, as they honor the lives and courage that inspired the world on 9/11.

For more than 30 years, Ohio investigators have searched for answers in the murder of 10-year-old Amy Mihaljevic. Now they're enlisting your help to solve the case. Josh Mankiewicz reports.